{"id":"W4411101847","doi":"10.1097/01.ogx.0001119032.48993.e7","title":"Prenatal Cell-Free DNA Screening for Chromosomal Aneuploidies After Euploid Embryo Transfer Shows High Concordance With Preimplantation Genetic Testing for Aneuploidy Results and Low Positive Predictive Values","year":2025,"lang":"en","type":"article","venue":"Obstetrical & Gynecological Survey","topic":"Prenatal Screening and Diagnostics","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"CReATe Fertility Centre; Sunnybrook Hospital; University of Toronto; Toronto Public Health; Sunnybrook Health Science Centre","funders":"","keywords":"Concordance; Aneuploidy; Medicine; Embryo; Ploidy; Genetic testing; Andrology; Cell-free fetal DNA; Genetics; Prenatal diagnosis; Fetus; Internal medicine; Pregnancy; Biology; Chromosome; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009714808,0.0002338141,0.0002458066,0.001492291,0.0001473061,0.0004058056,0.0002006321,0.0005078863,0.006930918],"category_scores_gemma":[0.006635663,0.0001283968,0.0001593825,0.0006350551,0.0003798684,0.0002321222,0.0002773233,0.0003571994,0.001240253],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002254647,"about_ca_system_score_gemma":0.0001478213,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002256564,"about_ca_topic_score_gemma":0.002155781,"domain_scores_codex":[0.9990822,0.0002166641,0.00009000889,0.0001329111,0.0003996324,0.00007862987],"domain_scores_gemma":[0.9966124,0.002253014,0.0004097997,0.0001303631,0.0004426852,0.0001517923],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0005117183,0.00009665346,0.929308,0.00009660544,0.00006527239,0.002478331,0.0002518745,0.0001709197,0.02960006,0.0002657733,0.001486522,0.03566823],"study_design_scores_gemma":[0.00001698629,0.0004068953,0.9648275,0.00005762599,0.0000416035,0.01174684,0.0002839826,0.0006944882,0.01874245,0.0002439765,0.002926625,0.0000110119],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9790507,0.003119054,0.002967492,0.0007039201,0.0001116955,0.00005139453,0.0009821834,0.00009598356,0.01291768],"genre_scores_gemma":[0.9943152,0.0008093624,0.001834998,0.0001675992,0.00002517563,0.00001363452,0.0006076674,0.00001000133,0.002216301],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006930918,"threshold_uncertainty_score":0.02318621,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02259329105928645,"score_gpt":0.2585106604880627,"score_spread":0.2359173694287763,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}