{"id":"W4411102757","doi":"10.1093/jscdis/yoaf013.015","title":"Design of the RHEMEDY Study: A Phase 2/3 Safety, Efficacy and Pharmacokinetics Study of CSL889 in Adults and Adolescents With Sickle Cell Disease During Vaso-Occlusive Crisis","year":2025,"lang":"en","type":"article","venue":"Journal of sickle cell disease.","topic":"Hemoglobinopathies and Related Disorders","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Vaso-occlusive crisis; Pharmacokinetics; Medicine; Disease; Sickle cell anemia; Internal medicine; Pharmacology","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.004352645,0.001510797,0.002675511,0.0004905533,0.0005411067,0.001329409,0.001028708,0.001837664,0.005707514],"category_scores_gemma":[0.00184422,0.0008700445,0.001644547,0.0004133457,0.001251559,0.001242791,0.0004956207,0.003935112,0.001904511],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001086974,"about_ca_system_score_gemma":0.002960361,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006060752,"about_ca_topic_score_gemma":0.001449706,"domain_scores_codex":[0.998744,0.0006525068,0.00006044259,0.0002012875,0.000119907,0.0002218246],"domain_scores_gemma":[0.9987411,0.0001417904,0.0002164479,0.0001164102,0.000153983,0.0006303406],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.7323723,0.1232622,0.0143399,0.001781335,0.002564692,0.000634962,0.000546304,0.002695232,0.04952573,0.0009050624,0.007682877,0.0636894],"study_design_scores_gemma":[0.4519603,0.5238498,0.01054583,0.00005508505,0.0009318351,0.0002466648,0.00009149939,0.00107873,0.003317729,0.0003391132,0.007530871,0.00005265092],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"protocol","genre_scores_codex":[0.9505395,0.002938749,0.002609332,0.00116014,0.0003596475,0.03641804,0.003369371,0.0002490222,0.00235616],"genre_scores_gemma":[0.9354944,0.001983737,0.006888405,0.002940341,0.0004509301,0.04417118,0.002877136,0.0001015936,0.005092195],"genre_candidate":"protocol","genre_consensus":null,"teacher_disagreement_score":0.005707514,"threshold_uncertainty_score":0.02301925,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005417700442188235,"score_gpt":0.2540955144500368,"score_spread":0.2486778140078486,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}