{"id":"W4411103372","doi":"10.1002/mus.28448","title":"Efficacy and Safety of Once Daily Dosing vs. Approved On/Off Dosing of Edaravone Oral Suspension Up to 48 Weeks in Patients With Amyotrophic Lateral Sclerosis (Study <scp>MT</scp>‐1186‐<scp>A02</scp>)","year":2025,"lang":"en","type":"article","venue":"Muscle & Nerve","topic":"Amyotrophic Lateral Sclerosis Research","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University Medical Centre; Health Sciences Centre; University of Toronto; Sunnybrook Health Science Centre; Montreal Neurological Institute and Hospital","funders":"Mitsubishi Tanabe Pharma Corporation","keywords":"Tolerability; Dosing; Edaravone; Medicine; Placebo; Regimen; Adverse effect; Anesthesia; Clinical endpoint; Clinical trial; Internal medicine; Surgery","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001332982,0.0008361377,0.00193109,0.0003516655,0.0002845131,0.0007995737,0.0006593934,0.001379018,0.002580298],"category_scores_gemma":[0.001671916,0.0004227996,0.001457348,0.0002661879,0.0006409263,0.0008733427,0.0002649275,0.001653031,0.0004318607],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006191703,"about_ca_system_score_gemma":0.0005601768,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00050348,"about_ca_topic_score_gemma":0.00111,"domain_scores_codex":[0.9993827,0.0002823799,0.00005193448,0.0001405338,0.00005975724,0.00008252163],"domain_scores_gemma":[0.9989834,0.0002646866,0.0003034723,0.0001059818,0.00007675646,0.0002656131],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.8910764,0.01633415,0.003511613,0.0004369477,0.0008352917,0.00006410859,0.0001197616,0.0006953432,0.01577775,0.00006775493,0.000634326,0.07044663],"study_design_scores_gemma":[0.328552,0.6445624,0.01904699,0.00005062881,0.0009059983,0.0001570638,0.00005909367,0.001126266,0.00423771,0.0001427679,0.001113862,0.00004522096],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9973168,0.001320838,0.0001025418,0.00008041262,0.00006604879,0.0002154216,0.0002578653,0.00003110011,0.0006089609],"genre_scores_gemma":[0.9979632,0.0004876556,0.0002784676,0.000140149,0.00008067727,0.0002337237,0.0003015062,0.000008394699,0.000506292],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002580298,"threshold_uncertainty_score":0.008631885,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02182849302672155,"score_gpt":0.2715553304610983,"score_spread":0.2497268374343768,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}