{"id":"W4411103372","doi":"10.1002/mus.28448","title":"Efficacy and Safety of Once Daily Dosing vs. Approved On/Off Dosing of Edaravone Oral Suspension Up to 48 Weeks in Patients With Amyotrophic Lateral Sclerosis (Study <scp>MT</scp>‐1186‐<scp>A02</scp>)","year":2025,"lang":"en","type":"article","venue":"Muscle & Nerve","topic":"Amyotrophic Lateral Sclerosis Research","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University Medical Centre; Health Sciences Centre; University of Toronto; Sunnybrook Health Science Centre; Montreal Neurological Institute and Hospital","funders":"Mitsubishi Tanabe Pharma Corporation","keywords":"Tolerability; Dosing; Edaravone; Medicine; Placebo; Regimen; Adverse effect; Anesthesia; Clinical endpoint; Clinical trial; Internal medicine; Surgery","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0008849165,0.0005612558,0.001310263,0.0007260096,0.0002273515,0.00008997446,0.0004016186,0.0002543406,0.0000153735],"category_scores_gemma":[0.000779785,0.0004591959,0.0001422974,0.001757791,0.0002827714,0.0002589648,0.0005687759,0.0008031901,0.00001352907],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003759709,"about_ca_system_score_gemma":0.0001970466,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001620757,"about_ca_topic_score_gemma":0.0001926618,"domain_scores_codex":[0.9950008,0.0004808108,0.001153326,0.001089794,0.001265209,0.001010066],"domain_scores_gemma":[0.9971848,0.000622477,0.0003552795,0.0009622163,0.0004815997,0.0003936561],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.007243879,0.005870266,0.7558634,0.0006713359,0.0005713778,0.0001046522,0.01407039,0.001299281,0.1712629,0.000134992,0.001235577,0.04167197],"study_design_scores_gemma":[0.01960702,0.003954113,0.9679772,0.002646996,0.0001544377,0.000001679855,0.0007672223,0.0006895717,0.003875118,0.00001217391,0.0001839848,0.0001304563],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9957941,0.0001516191,0.00004330005,0.0002675988,0.0002326897,0.002911262,0.0000257948,0.00007022582,0.0005034359],"genre_scores_gemma":[0.9982524,0.00004264271,0.0005878775,0.0002500372,0.00006413253,0.00005632283,0.00004663253,0.00008810601,0.0006118776],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2121138,"threshold_uncertainty_score":0.999786,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02182849302672155,"score_gpt":0.2715553304610983,"score_spread":0.2497268374343768,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}