{"id":"W4411116442","doi":"10.1038/s41531-025-01012-0","title":"Brain-clinical biotyping in patients with idiopathic REM sleep behavior disorder","year":2025,"lang":"en","type":"article","venue":"npj Parkinson s Disease","topic":"Parkinson's Disease Mechanisms and Treatments","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canadian Sleep & Circadian Network; Hôpital du Sacré-Cœur de Montréal; Université du Québec à Montréal","funders":"Health and Medical Research Fund; Food and Health Bureau","keywords":"Synucleinopathies; REM sleep behavior disorder; Neurocognitive; Neuroscience; Polysomnography; Atrophy; Parkinson's disease; Medicine; Psychology; Disease; Alpha-synuclein; Cognition; Pathology; Electroencephalography","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001989476,0.0003295766,0.0003211153,0.001003968,0.0003509287,0.0002921882,0.0001511151,0.0002540326,0.0007801374],"category_scores_gemma":[0.0009438638,0.0001413783,0.0001849143,0.0005392267,0.000305466,0.0002686721,0.0004373229,0.0001759979,0.0001511638],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002681163,"about_ca_system_score_gemma":0.000184635,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003708426,"about_ca_topic_score_gemma":0.009038742,"domain_scores_codex":[0.9998672,0.00002632482,0.00001829596,0.00004388195,0.00002520255,0.00001923778],"domain_scores_gemma":[0.9997135,0.00004274895,0.0001433138,0.00002438397,0.00003318903,0.00004291299],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0003112452,0.00002135442,0.9926654,0.000008772883,0.00002964589,0.0004597803,0.0001404711,0.0001497622,0.003193133,0.00002582446,0.00004351812,0.002951001],"study_design_scores_gemma":[0.000004564036,0.00008350874,0.9981945,0.000002212051,0.000008095377,0.0009980701,0.0001099143,0.0003493989,0.0001581227,0.00005266574,0.00003662003,0.000002226626],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9996512,0.00003820925,0.00006767474,0.000005950656,7.67087e-7,0.000006270788,0.00006276416,0.000001569646,0.0001655916],"genre_scores_gemma":[0.9997076,0.00001611361,0.00009290595,0.000004417049,0.000001258484,0.000003390805,0.0001252677,8.743301e-7,0.00004801486],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003708426,"threshold_uncertainty_score":0.007373691,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01376557651084365,"score_gpt":0.2978398290175309,"score_spread":0.2840742525066873,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}