{"id":"W4411121742","doi":"10.1007/s00262-025-04088-y","title":"NLRP3 activation promotes cGAS/STING signaling and antitumor immunity by colorectal cancer cells","year":2025,"lang":"en","type":"article","venue":"Cancer Immunology Immunotherapy","topic":"interferon and immune responses","field":"Immunology and Microbiology","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"Royal Alexandra Hospital; University of Alberta","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; University Hospital Foundation; University of Alberta","keywords":"Sting; Cancer research; Immunity; Colorectal cancer; Signal transduction; Medicine; Immunology; Cancer; Biology; Immune system; Internal medicine; Cell biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002060041,0.0004074187,0.0003511528,0.0002321264,0.0001520783,0.0003487869,0.0001242126,0.000285375,0.001791931],"category_scores_gemma":[0.0001322737,0.0001049481,0.0004628974,0.0002324764,0.0002618461,0.0002176639,0.0002518782,0.0008681208,0.0005569278],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003186848,"about_ca_system_score_gemma":0.0002493566,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003440017,"about_ca_topic_score_gemma":0.0004814188,"domain_scores_codex":[0.9997866,0.00004379255,0.00002360327,0.00003786959,0.00004991274,0.00005822677],"domain_scores_gemma":[0.9998901,0.00002120908,0.00003130702,0.00001791767,0.00001098511,0.00002848637],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004234413,0.00006552938,0.0002860806,0.0000800595,0.000005971262,0.00006061841,0.00002836114,0.00008284558,0.9972904,0.00004689502,0.00008558665,0.001544216],"study_design_scores_gemma":[0.00007325262,0.001149314,0.009402051,0.00001653441,0.00002250478,0.0004154739,0.00005091171,0.001601893,0.9841475,0.00007667457,0.003036226,0.000007643361],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9928197,0.002254822,0.002459575,0.000152452,0.00004747853,0.00007219851,0.0004912686,0.0001777597,0.00152472],"genre_scores_gemma":[0.9967193,0.0005072746,0.001442734,0.00006043286,0.00001428777,0.00006059086,0.0004308843,0.000009933006,0.0007545737],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001791931,"threshold_uncertainty_score":0.005994558,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009776076470840942,"score_gpt":0.2748164852944155,"score_spread":0.2650404088235745,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}