{"id":"W4411135430","doi":"10.1210/clinem/dgaf336","title":"Efficacy of GLP-1-based Therapies on Metabolic Dysfunction-associated Steatotic Liver Disease and Metabolic Dysfunction-associated Steatohepatitis: A Systematic Review and Meta-analysis","year":2025,"lang":"en","type":"review","venue":"The Journal of Clinical Endocrinology & Metabolism","topic":"Liver Disease Diagnosis and Treatment","field":"Medicine","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Ministry of Science and Technology, Government of the People’s Republic of Bangladesh; National Natural Science Foundation of China","keywords":"Steatohepatitis; Meta-analysis; Medicine; Fatty liver; Disease; Liver dysfunction; Internal medicine; Liver enzyme; Metabolic disease; Steatosis; Bioinformatics; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01026151,0.00235562,0.0188876,0.00574863,0.0005098364,0.002594296,0.001824845,0.00194712,0.003175844],"category_scores_gemma":[0.02093856,0.00127657,0.03070181,0.006271679,0.0006106331,0.001445981,0.001139618,0.001302539,0.0002432442],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001842951,"about_ca_system_score_gemma":0.002809923,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004689281,"about_ca_topic_score_gemma":0.01062152,"domain_scores_codex":[0.9938029,0.002775181,0.001933683,0.0006205547,0.0006785583,0.0001890256],"domain_scores_gemma":[0.9875922,0.008528796,0.002411568,0.0003195779,0.0009716788,0.000176274],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"meta_analysis","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.002011882,0.00003462198,0.002951193,0.4436536,0.5367751,0.0001039688,0.00005588352,0.0005179784,0.0002831034,0.0001048164,0.0004934957,0.01301431],"study_design_scores_gemma":[0.0006543066,0.0002313416,0.002844901,0.02616326,0.9684733,0.00007848036,0.00002938936,0.0001661067,0.0001075484,0.0001024914,0.001129743,0.00001905688],"study_design_candidate":"meta_analysis","study_design_consensus":"meta_analysis","genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00406938,0.9946795,0.000295331,0.0001422685,0.00009829053,0.0001999389,0.0003233946,0.00001548862,0.0001763864],"genre_scores_gemma":[0.1412481,0.854359,0.00166434,0.0007193236,0.0002556465,0.0008512755,0.0006321719,0.00002022522,0.0002500337],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.0188876,"threshold_uncertainty_score":0.05426866,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08399566566677545,"score_gpt":0.3865057092136737,"score_spread":0.3025100435468982,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}