{"id":"W4411141147","doi":"10.1200/jco-24-01893","title":"International Myeloma Society/International Myeloma Working Group Consensus Recommendations on the Definition of High-Risk Multiple Myeloma","year":2025,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Multiple Myeloma Research and Treatments","field":"Medicine","cited_by":134,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; Institute of Cancer Research; University of Calgary","funders":"National Cancer Institute; National Institutes of Health","keywords":"Medicine; Multiple myeloma; Context (archaeology); Oncology; Internal medicine; Risk stratification; Clinical trial; Fluorescence in situ hybridization; Clinical Practice; Intensive care medicine; Family medicine; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0378813,0.001994501,0.003496852,0.008194464,0.002489424,0.005267666,0.009702161,0.006720076,0.006261482],"category_scores_gemma":[0.04343523,0.001017687,0.005738988,0.006935409,0.002257307,0.00335788,0.005701448,0.01099217,0.005300502],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.007094312,"about_ca_system_score_gemma":0.02848878,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.02480943,"about_ca_topic_score_gemma":0.01854482,"domain_scores_codex":[0.9744675,0.01032597,0.005495729,0.001168687,0.007027559,0.0015146],"domain_scores_gemma":[0.9536796,0.008471069,0.004170169,0.001171747,0.02970462,0.002802818],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002324269,0.0002287543,0.005007792,0.006317268,0.0003310112,0.0003178535,0.0006819806,0.0009424633,0.000654549,0.01059897,0.7704758,0.204211],"study_design_scores_gemma":[0.0002629164,0.0001180453,0.008113512,0.02009338,0.0005429519,0.001024084,0.001117293,0.0007733167,0.0007744665,0.01562184,0.9514413,0.0001168936],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"other","genre_scores_codex":[0.006296255,0.3740458,0.0550847,0.4026517,0.03874989,0.008533453,0.01250106,0.001500948,0.1006362],"genre_scores_gemma":[0.05631028,0.3217369,0.2978159,0.196116,0.01762053,0.01676681,0.05362445,0.0009768141,0.03903219],"genre_candidate":"other","genre_consensus":null,"teacher_disagreement_score":0.0378813,"threshold_uncertainty_score":0.2003378,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.156085313055728,"score_gpt":0.4504290073324454,"score_spread":0.2943436942767174,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}