{"id":"W4411142164","doi":"10.1093/g3journal/jkaf132","title":"New alleles of D-2-hydroxyglutarate dehydrogenase enable studies of oncometabolite function in <i>Drosophila melanogaster</i>","year":2025,"lang":"en","type":"article","venue":"G3 Genes Genomes Genetics","topic":"Amino Acid Enzymes and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of General Medical Sciences; McMaster Institute for Research on Aging, McMaster University; National Institutes of Health; National Human Genome Research Institute; American Heart Association","keywords":"Biology; Context (archaeology); Ectopic expression; Genetics; Isocitrate dehydrogenase; Drosophila melanogaster; Allele; Phenotype; Mutation; Cancer research; Gene; Biochemistry; Enzyme","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001955024,0.0006146837,0.0001830076,0.0005449555,0.0003219761,0.0003493768,0.000523235,0.0004923346,0.002025898],"category_scores_gemma":[0.0001334204,0.0002967046,0.0004693296,0.0001781848,0.0004414753,0.0002243274,0.0004351028,0.0008499338,0.0006338354],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008314803,"about_ca_system_score_gemma":0.0002844558,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001608471,"about_ca_topic_score_gemma":0.004049398,"domain_scores_codex":[0.9997832,0.00003323217,0.00004198049,0.00005164796,0.00006187762,0.00002815441],"domain_scores_gemma":[0.9997554,0.00004973324,0.00008775925,0.00003193801,0.00002204655,0.00005313798],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005274495,0.00001698215,0.0003227971,0.00003579165,0.000006732399,0.000119143,0.00003084292,0.0000839315,0.9973694,0.0005549263,0.0001100825,0.001296481],"study_design_scores_gemma":[0.00004800927,0.0001656485,0.008907215,0.00002764428,0.00003133494,0.0007970491,0.00006659906,0.001367376,0.9701324,0.0001156127,0.01832221,0.00001893459],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9499019,0.001894513,0.02884265,0.000673405,0.0001455182,0.0004036091,0.006472707,0.0005711261,0.01109447],"genre_scores_gemma":[0.9411783,0.001907022,0.0338512,0.0003446162,0.00003785563,0.0003165529,0.005334612,0.0003512106,0.01667877],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002025898,"threshold_uncertainty_score":0.006777346,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01431296597626513,"score_gpt":0.2692997777821998,"score_spread":0.2549868118059346,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}