{"id":"W4411146709","doi":"10.2337/dc24-2629","title":"Effect of Efpeglenatide on Heart Failure Outcomes: A Participant-Level Exploratory Analysis of the Randomized AMPLITUDE-O Trial","year":2025,"lang":"en","type":"letter","venue":"Diabetes Care","topic":"Health Systems, Economic Evaluations, Quality of Life","field":"Economics, Econometrics and Finance","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Population Health Research Institute","funders":"Medical Research Council; National Institutes of Health; Impulse Dynamics; National Medical Research Council; Cytokinetics; Amarin Corporation; Boston Scientific Corporation; GlaxoSmithKline; Bristol-Myers Squibb; Eli Lilly and Company; AstraZeneca; McMaster University; Amgen; Pfizer; Novo Nordisk; ReCor Medical; Intarcia Therapeutics; Daiichi Sankyo Europe; Kowa Company; Sanofi; Abbott Laboratories","keywords":"Medicine; Randomized controlled trial; Heart failure; Diabetes mellitus; Exploratory analysis; Internal medicine; Physical therapy; Endocrinology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01365045,0.000881754,0.002126301,0.0003000763,0.0003729026,0.001256766,0.000685892,0.003254339,0.005504563],"category_scores_gemma":[0.03499926,0.0003441052,0.003877415,0.0004903395,0.0009455303,0.001442628,0.0008142277,0.002823067,0.0006171621],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009756706,"about_ca_system_score_gemma":0.001901587,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002133025,"about_ca_topic_score_gemma":0.005124767,"domain_scores_codex":[0.9871429,0.0110625,0.0004899866,0.0004557001,0.0004688708,0.000380118],"domain_scores_gemma":[0.9745083,0.01970058,0.002769799,0.001357712,0.0007159883,0.0009475459],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"observational","study_design_scores_codex":[0.905392,0.001254623,0.01181932,0.001623113,0.01111537,0.0003553442,0.0001376113,0.0006753993,0.001124391,0.001221567,0.01400979,0.05127142],"study_design_scores_gemma":[0.892671,0.02939974,0.03759516,0.001049984,0.01966029,0.0002459605,0.0002526858,0.002488061,0.001083547,0.005038182,0.01036988,0.0001454416],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8862597,0.02133816,0.004292944,0.05252733,0.00406639,0.003871235,0.01328231,0.0002858293,0.01407616],"genre_scores_gemma":[0.9628783,0.003008096,0.004117018,0.02030027,0.001548102,0.002214279,0.002068097,0.00007316756,0.003792643],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01365045,"threshold_uncertainty_score":0.0721913,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2178882398880897,"score_gpt":0.4004539324110017,"score_spread":0.1825656925229121,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}