{"id":"W4411148433","doi":"10.1016/j.jtha.2025.05.033","title":"Apolipoprotein A-IV regulates coagulation and ischemic stroke by potentiating activated protein C","year":2025,"lang":"en","type":"article","venue":"Journal of Thrombosis and Haemostasis","topic":"Blood Coagulation and Thrombosis Mechanisms","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":false,"ca_institutions":"Canadian Blood Services; St. Michael's Hospital","funders":"Shandong Provincial Postdoctoral Science Foundation; Qingdao University; Natural Science Foundation of Shandong Province; Qingdao Key Health Discipline Development Fund; Taishan Scholar Foundation of Shandong Province; National Natural Science Foundation of China; Heart and Stroke Foundation of Canada","keywords":"Coagulation; Ischemic stroke; Protein C; Stroke (engine); Apolipoprotein B; Medicine; Internal medicine; Chemistry; Cholesterol; Ischemia","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002646819,0.0004305934,0.0002928433,0.0004427804,0.0002739214,0.0006102409,0.0003384102,0.0004337911,0.001931066],"category_scores_gemma":[0.0005005775,0.0002522452,0.0005526238,0.0001627429,0.0004224767,0.0001880983,0.0003474788,0.0006657845,0.0005032821],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006036916,"about_ca_system_score_gemma":0.0003422662,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001088357,"about_ca_topic_score_gemma":0.0006386528,"domain_scores_codex":[0.9997393,0.00008672442,0.00001959814,0.00004091726,0.00003408413,0.00007931398],"domain_scores_gemma":[0.9997651,0.00003811915,0.00008007835,0.00002929176,0.00002750599,0.00005988995],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.009813537,0.0005027661,0.007197528,0.0001288612,0.0002933464,0.001080885,0.00005498229,0.0004376079,0.9669999,0.001246614,0.0007663979,0.01147754],"study_design_scores_gemma":[0.002198616,0.005921921,0.2819494,0.00009171578,0.001033154,0.004319022,0.0003757504,0.008800228,0.6771424,0.004911644,0.01314739,0.0001086515],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9929795,0.002407531,0.0014412,0.0003385536,0.0001106585,0.00002948981,0.0001064476,0.00008533965,0.00250131],"genre_scores_gemma":[0.9963031,0.0009080252,0.0008617584,0.0001284955,0.00006771522,0.00002410984,0.0001397074,0.00002072041,0.001546318],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001931066,"threshold_uncertainty_score":0.006460071,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02529559955128649,"score_gpt":0.2961177305110935,"score_spread":0.270822130959807,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}