{"id":"W4411152964","doi":"10.1002/ehf2.15262","title":"Optimization of Renin-Angiotensin-Aldosterone Inhibitor Therapies for Evidence-Based Indications: A Call to Action From the Cardio-Kidney Community","year":2025,"lang":"en","type":"editorial","venue":"ESC Heart Failure","topic":"Heart Failure Treatment and Management","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Southlake Regional Health Center; University of British Columbia","funders":"AstraZeneca","keywords":"Medicine; Renin–angiotensin system; Heart failure; Aldosterone; Action (physics); ACE inhibitor; Call to action; Internal medicine; Kidney; Renin inhibitor; Endocrinology; Angiotensin-converting enzyme; Blood pressure","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0009995385,0.000430071,0.0009122982,0.0002981676,0.0004147158,0.00008319451,0.0002750329,0.0007077947,0.00006601671],"category_scores_gemma":[0.003686673,0.0003197482,0.0004096494,0.0004799817,0.0001085189,0.0001451557,0.0001311676,0.0008705911,0.00002071268],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003472474,"about_ca_system_score_gemma":0.0013272,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002347872,"about_ca_topic_score_gemma":0.0005761301,"domain_scores_codex":[0.9971742,0.0006314334,0.0006126518,0.0004615797,0.0007932754,0.0003268845],"domain_scores_gemma":[0.9945439,0.002839787,0.0002508301,0.001316621,0.0008354814,0.0002134447],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0004994627,0.0001905489,0.0003890222,0.000252737,0.0006206914,0.000001017482,0.0006889222,0.0002271563,0.000441054,0.000006175545,0.9960007,0.0006825332],"study_design_scores_gemma":[0.001833423,0.0007113168,0.0004881582,0.003672599,0.001202867,4.507933e-7,0.000228487,0.0001284419,0.0009873087,0.00001602632,0.9904965,0.0002344314],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"editorial","genre_scores_codex":[0.001529998,0.002263936,0.03563655,0.6601086,0.2824386,0.01462246,0.00286434,0.0004659038,0.00006959018],"genre_scores_gemma":[0.01922707,0.0006131545,0.3597103,0.01025578,0.5774076,0.003295053,0.02195968,0.0002978794,0.007233479],"genre_candidate":"editorial","genre_consensus":null,"teacher_disagreement_score":0.6498528,"threshold_uncertainty_score":0.9999254,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03520568682191517,"score_gpt":0.3138966787353209,"score_spread":0.2786909919134057,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}