{"id":"W4411158808","doi":"10.21203/rs.3.rs-6194507/v1","title":"Highly replicating hepatitis C virus variants emerge in immunosuppressed patients causing severe disease","year":2025,"lang":"en","type":"preprint","venue":"Research Square","topic":"Hepatitis C virus research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Centre Hospitalier de l’Université de Montréal","funders":"Instituto de Salud Carlos III; Canadian Institutes of Health Research; Deutsche Forschungsgemeinschaft; Centres de Recerca de Catalunya; National Institutes of Health; Generalitat de Catalunya; National Institute of Allergy and Infectious Diseases; European Commission; Deutsches Zentrum für Infektionsforschung","keywords":"Viral quasispecies; Biology; Viral replication; Hepatocellular carcinoma; Pathogenesis; Hepatitis C virus; Virology; Viral evolution; Viral pathogenesis; Liver disease; Virus; Disease; Genome; Phenotype; Genetics; Immunology; Gene; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00020692,0.0002237067,0.0003341871,0.0004381656,0.0003764223,0.0007623106,0.0001234038,0.0005371773,0.003472447],"category_scores_gemma":[0.002409403,0.0001627366,0.0001492202,0.0003917718,0.0002805542,0.000269121,0.0002564112,0.000604021,0.0004919169],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009106818,"about_ca_system_score_gemma":0.00009506299,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002650511,"about_ca_topic_score_gemma":0.0001711095,"domain_scores_codex":[0.9998104,0.00004567374,0.00002108052,0.0000372475,0.00003086561,0.00005473667],"domain_scores_gemma":[0.9989516,0.0004334395,0.0002797378,0.00009134569,0.00007643289,0.0001674536],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00404739,0.0002559874,0.8789421,0.00009841786,0.00008137478,0.01321191,0.001118731,0.0002190086,0.06980925,0.0007730667,0.001919828,0.02952297],"study_design_scores_gemma":[0.00008607414,0.0008035401,0.9724725,0.00002409477,0.00007168155,0.01589265,0.001159255,0.0005434469,0.005838923,0.000785765,0.002305324,0.00001669625],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.998403,0.0002690923,0.0001534778,0.0000875554,0.00002474007,0.000008338232,0.00008123145,0.000008681842,0.0009638027],"genre_scores_gemma":[0.9990587,0.0001181339,0.0001266828,0.00009193064,0.00009949025,0.000004348569,0.0001172431,0.00000896311,0.0003745023],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003472447,"threshold_uncertainty_score":0.01161647,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05853451118109309,"score_gpt":0.4109841349651501,"score_spread":0.352449623784057,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}