{"id":"W4411163281","doi":"10.1016/j.cca.2025.120423","title":"Genetic landscape of primary ovarian insufficiency in Bangladeshi women through whole exome sequencing","year":2025,"lang":"en","type":"article","venue":"Clinica Chimica Acta","topic":"Ovarian function and disorders","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Genome Canada","funders":"","keywords":"Exome sequencing; Sanger sequencing; Premature ovarian insufficiency; Exome; Premature ovarian failure; Genetics; Population; Biology; Infertility; Medicine; Internal medicine; Gene; Mutation; Pregnancy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002342097,0.0003386614,0.0002722579,0.0008197751,0.0004370463,0.0005122825,0.0002977407,0.0004025303,0.004097619],"category_scores_gemma":[0.0009925937,0.000194864,0.0003201838,0.001457733,0.0002127981,0.0001934124,0.000498377,0.0003222294,0.0003725453],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002512117,"about_ca_system_score_gemma":0.0002495726,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005949726,"about_ca_topic_score_gemma":0.005754187,"domain_scores_codex":[0.9997662,0.00003618078,0.00002754309,0.0000900212,0.00003768544,0.00004247988],"domain_scores_gemma":[0.999778,0.0000918732,0.00005731896,0.00001775801,0.00002664222,0.00002842622],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.000904866,0.00004586248,0.9309487,0.0001822731,0.0004130604,0.01009112,0.001368168,0.0006263591,0.03096949,0.0005328481,0.001481125,0.02243614],"study_design_scores_gemma":[0.00003491538,0.000103027,0.9819474,0.00008928878,0.0002881637,0.008826084,0.00160118,0.0005322853,0.001613906,0.000692531,0.004245699,0.00002551556],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9947186,0.0007145858,0.0002954497,0.0003123748,0.00000957877,0.00001952469,0.002349943,0.000008088587,0.001571933],"genre_scores_gemma":[0.9980872,0.0003443254,0.0002353231,0.00008526204,0.000006245359,0.00001337265,0.0006735132,0.000006782669,0.0005480686],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005949726,"threshold_uncertainty_score":0.01370788,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02621252195701672,"score_gpt":0.2864311265216749,"score_spread":0.2602186045646582,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}