{"id":"W4411164077","doi":"10.1021/acs.molpharmaceut.5c00214","title":"In Vitro and In Vivo Study of Novel PSMA-Targeted Radioligands: Enhancing Tumor Uptake and Therapeutic Efficacy through Zwitterionization and Albumin-Binding Strategies","year":2025,"lang":"en","type":"article","venue":"Molecular Pharmaceutics","topic":"Radiopharmaceutical Chemistry and Applications","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Windsor","funders":"Southwest Medical University; National Natural Science Foundation of China","keywords":"Biodistribution; Radioligand; Chemistry; In vivo; Pharmacokinetics; In vitro; Pharmacology; Prostate cancer; Ligand (biochemistry); Spect imaging; Cancer research; Nuclear medicine; Medicine; Cancer; Biochemistry; Receptor; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003129659,0.0005335954,0.0002920414,0.0001806472,0.00008792581,0.000172589,0.0002058974,0.0002837738,0.0006177014],"category_scores_gemma":[0.0001634056,0.0001533786,0.000174847,0.0001446425,0.0001674941,0.0002216515,0.0001008831,0.0003723368,0.0002395283],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002923699,"about_ca_system_score_gemma":0.0002251296,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001067959,"about_ca_topic_score_gemma":0.001116019,"domain_scores_codex":[0.9998814,0.00003651863,0.000008282711,0.00002568456,0.00002378686,0.00002437063],"domain_scores_gemma":[0.9999335,0.00001918051,0.00002161847,0.000005422586,0.00001056788,0.000009768885],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000881515,0.00003664469,0.00004580647,0.00002810675,0.000003373027,0.00001726867,0.0000109356,0.0000865152,0.9987581,0.00003699188,0.00001726742,0.0008709315],"study_design_scores_gemma":[0.00001875269,0.001316895,0.0005377439,0.000001278344,0.00001645246,0.0001018041,0.000007651694,0.0009396283,0.9961802,0.00001052045,0.0008656736,0.000003445118],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9897296,0.002787331,0.006313726,0.00006148659,0.00002208964,0.00006925706,0.000122298,0.00006630916,0.0008277883],"genre_scores_gemma":[0.984894,0.00250149,0.009262312,0.00005484107,0.00001712534,0.0001118217,0.0003139876,0.0000270782,0.002817295],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001067959,"threshold_uncertainty_score":0.002123415,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02899334349651702,"score_gpt":0.3558144898896723,"score_spread":0.3268211463931553,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}