{"id":"W4411176523","doi":"10.1172/jci186065","title":"TNF-α impairs platelet function by inhibiting autophagy and disrupting metabolism via syntaxin 17 downregulation","year":2025,"lang":"en","type":"article","venue":"Journal of Clinical Investigation","topic":"Autophagy in Disease and Therapy","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Bioinformatics Solutions (Canada)","funders":"National Institute of Arthritis and Musculoskeletal and Skin Diseases; National Heart, Lung, and Blood Institute; University of Colorado School of Medicine, Anschutz Medical Campus; Anschutz Medical Campus, University of Colorado; Uniformed Services University of the Health Sciences","keywords":"Downregulation and upregulation; Autophagy; Cell biology; Function (biology); Metabolism; Chemistry; Platelet; Tumor necrosis factor alpha; Biology; Immunology; Biochemistry; Gene; Apoptosis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001852655,0.0002486939,0.0002633423,0.0001837369,0.0001436703,0.0003315042,0.0001247766,0.0002288115,0.0007732224],"category_scores_gemma":[0.0001103578,0.0001036044,0.0003183921,0.0001573443,0.000250356,0.0002188814,0.0001258203,0.0005085417,0.0001804492],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002699732,"about_ca_system_score_gemma":0.0003287015,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003803698,"about_ca_topic_score_gemma":0.0005200281,"domain_scores_codex":[0.9998485,0.00003650392,0.00002981216,0.00002146057,0.0000275851,0.00003623321],"domain_scores_gemma":[0.9999244,0.000009929677,0.00003071675,0.000009255636,0.00000802755,0.00001763554],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009682918,0.0001036974,0.0004868956,0.0001185661,0.00002383323,0.0001254216,0.00002299578,0.000180841,0.9944789,0.0002743755,0.0001192335,0.003096862],"study_design_scores_gemma":[0.0001120904,0.001235667,0.004735842,0.00002030765,0.00005687025,0.000591372,0.00005796537,0.001310778,0.9882715,0.0001461919,0.003454468,0.000006891752],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9911886,0.004467528,0.0021201,0.0002232939,0.00006729006,0.00003157397,0.0003169148,0.00007332616,0.001511331],"genre_scores_gemma":[0.9952118,0.002044048,0.001173662,0.00007970117,0.00001272164,0.0000366819,0.0002527799,0.000008572468,0.00118012],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007732224,"threshold_uncertainty_score":0.002586663,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02754065567791958,"score_gpt":0.3563512672943385,"score_spread":0.3288106116164189,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}