{"id":"W4411187552","doi":"10.1038/s41562-025-02193-7","title":"Genetics of monozygotic twins reveals the impact of environmental sensitivity on psychiatric and neurodevelopmental phenotypes","year":2025,"lang":"en","type":"review","venue":"Nature Human Behaviour","topic":"Cognitive Abilities and Testing","field":"Psychology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Research Unit on Children's Psychosocial Maladjustment; Child, Adolescent and Family Mental Health","funders":"FP7 Health; National Institute on Alcohol Abuse and Alcoholism; European Regional Development Fund; National Health and Medical Research Council; Medical Research Council; Forsknings- og Innovationsstyrelsen; National Institutes of Health; Barts Health NHS Trust; St George's University Hospitals NHS Foundation Trust; Science for Life Laboratory; Sigrid Juséliuksen Säätiö; Young and Well Cooperative Research Centre; University of Bristol; Wellcome Trust; University College London; King's College London; Forskningsrådet för Arbetsliv och Socialvetenskap; National Institute on Aging; Queen Mary University of London; Commonwealth Scientific and Industrial Research Organisation; National Institute for Health and Care Research; Vetenskapsrådet; Versus Arthritis; Australian Government; Riksbankens Jubileumsfond; Vårdalstiftelsen; European Commission; Broad Institute; Ministerio de Ciencia, Innovación y Universidades; National Institute of Mental Health; Danish Agency for Science and Higher Education; QIMR Berghofer Medical Research Institute; Norges Forskningsråd; Chronic Disease Research Foundation; NIHR Maudsley Biomedical Research Centre; Wellcome; Jacobs Foundation; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; John D. and Catherine T. MacArthur Foundation","keywords":"Phenotype; Genetics; Twin study; Psychiatric genetics; Behavioural genetics; Sensitivity (control systems); Psychiatry; Medicine; Psychology; Biology; Heritability; Gene; Schizophrenia (object-oriented programming)","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003290256,0.0004316422,0.001054674,0.0002289763,0.0001318631,0.00001364363,0.0002009113,0.0004964346,0.0002119199],"category_scores_gemma":[0.00006337739,0.0002940618,0.0004933256,0.0002089672,0.0001973067,0.00001678197,0.0001633059,0.001169191,0.000004885011],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009482774,"about_ca_system_score_gemma":0.00008913487,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006405311,"about_ca_topic_score_gemma":0.0000120166,"domain_scores_codex":[0.99796,0.0004835805,0.0005970789,0.0004914962,0.0002065812,0.0002613112],"domain_scores_gemma":[0.9981172,0.0007923566,0.0005296014,0.0004771453,0.00003200865,0.00005165487],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.00003131455,0.001004865,0.08289403,0.003260874,0.0005001389,0.00004343325,0.0007838217,8.769483e-7,0.00002944696,0.0005043412,0.0008538538,0.910093],"study_design_scores_gemma":[0.0004275942,0.0005236202,0.9924243,0.002494751,0.001548691,0.00009603551,0.0001675641,4.841908e-7,0.000002952664,0.0001551957,0.001735763,0.0004230474],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"review","genre_gemma":"empirical","genre_scores_codex":[0.3182182,0.6789391,4.785522e-7,0.000003583319,0.0002249783,0.0007015705,0.0006983776,0.0000116437,0.00120207],"genre_scores_gemma":[0.720911,0.2783842,0.00003827663,0.0000262139,0.00009650092,0.00002203446,0.00009018887,0.00004178034,0.0003897651],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.9096699,"threshold_uncertainty_score":0.9999511,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03219826572730854,"score_gpt":0.3651557880805644,"score_spread":0.3329575223532558,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}