{"id":"W4411187552","doi":"10.1038/s41562-025-02193-7","title":"Genetics of monozygotic twins reveals the impact of environmental sensitivity on psychiatric and neurodevelopmental phenotypes","year":2025,"lang":"en","type":"review","venue":"Nature Human Behaviour","topic":"Cognitive Abilities and Testing","field":"Psychology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Research Unit on Children's Psychosocial Maladjustment; Child, Adolescent and Family Mental Health","funders":"FP7 Health; National Institute on Alcohol Abuse and Alcoholism; European Regional Development Fund; National Health and Medical Research Council; Medical Research Council; Forsknings- og Innovationsstyrelsen; National Institutes of Health; Barts Health NHS Trust; St George's University Hospitals NHS Foundation Trust; Science for Life Laboratory; Sigrid Juséliuksen Säätiö; Young and Well Cooperative Research Centre; University of Bristol; Wellcome Trust; University College London; King's College London; Forskningsrådet för Arbetsliv och Socialvetenskap; National Institute on Aging; Queen Mary University of London; Commonwealth Scientific and Industrial Research Organisation; National Institute for Health and Care Research; Vetenskapsrådet; Versus Arthritis; Australian Government; Riksbankens Jubileumsfond; Vårdalstiftelsen; European Commission; Broad Institute; Ministerio de Ciencia, Innovación y Universidades; National Institute of Mental Health; Danish Agency for Science and Higher Education; QIMR Berghofer Medical Research Institute; Norges Forskningsråd; Chronic Disease Research Foundation; NIHR Maudsley Biomedical Research Centre; Wellcome; Jacobs Foundation; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; John D. and Catherine T. MacArthur Foundation","keywords":"Phenotype; Genetics; Twin study; Psychiatric genetics; Behavioural genetics; Sensitivity (control systems); Psychiatry; Medicine; Psychology; Biology; Heritability; Gene; Schizophrenia (object-oriented programming)","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002912861,0.0005087847,0.000815246,0.001395187,0.00084107,0.0009393964,0.0004638026,0.0005799634,0.001475236],"category_scores_gemma":[0.0073313,0.0004419004,0.0008033763,0.001536365,0.0006537174,0.0002739776,0.0009853138,0.0007398172,0.0001418265],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00032145,"about_ca_system_score_gemma":0.0004509588,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00660926,"about_ca_topic_score_gemma":0.01042551,"domain_scores_codex":[0.9966881,0.001673117,0.0002296422,0.0007794976,0.0004537391,0.0001759313],"domain_scores_gemma":[0.9971654,0.001057281,0.0006192794,0.0006567243,0.0002804137,0.0002208926],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0007887145,0.00006630262,0.9669009,0.00008110609,0.002499903,0.001027773,0.00076836,0.0003281448,0.01890228,0.00064199,0.0003190187,0.007675537],"study_design_scores_gemma":[0.00001498698,0.0000903125,0.9952471,0.00002699371,0.0005131857,0.00132496,0.000221967,0.0006335315,0.001181105,0.0004199955,0.0003171191,0.000008703298],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"review","genre_scores_codex":[0.9970905,0.0006187382,0.001499253,0.0000783448,0.00001909998,0.00001553416,0.000208841,0.000009100867,0.0004605574],"genre_scores_gemma":[0.9985088,0.0001542896,0.001010938,0.00003345568,0.000006712532,0.00001174776,0.0001298586,0.000008001826,0.0001362325],"genre_candidate":"review","genre_consensus":null,"teacher_disagreement_score":0.00660926,"threshold_uncertainty_score":0.01540488,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03219826572730854,"score_gpt":0.3651557880805644,"score_spread":0.3329575223532558,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}