{"id":"W4411191755","doi":"10.1111/mmi.70000","title":"<scp> <i>Staphylococcus aureus</i> COL </scp> : An Atypical Model Strain of <scp>MRSA</scp> That Exhibits Slow Growth and Antibiotic Tolerance due to a Mutation in <scp>PRPP</scp> Synthetase","year":2025,"lang":"en","type":"article","venue":"Molecular Microbiology","topic":"Antimicrobial Resistance in Staphylococcus","field":"Medicine","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Victoria","funders":"Canadian Institutes of Health Research; Biotechnology and Biological Sciences Research Council; Academy of Medical Sciences","keywords":"Staphylococcus aureus; Biology; Microbiology; Antibiotics; Strain (injury); Methicillin-resistant Staphylococcus aureus; Mutation; Bacteria; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006659201,0.0004671009,0.0002234285,0.0002530111,0.0001839478,0.0003266515,0.0002779758,0.0004010784,0.0005486732],"category_scores_gemma":[0.0001509709,0.00009266399,0.0002324349,0.000243683,0.0002548824,0.0001213419,0.0002140606,0.0004875926,0.0003190232],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002621543,"about_ca_system_score_gemma":0.000218199,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001557186,"about_ca_topic_score_gemma":0.001797219,"domain_scores_codex":[0.9997823,0.00004043377,0.00002068289,0.00004306304,0.00006978679,0.00004366379],"domain_scores_gemma":[0.9998454,0.00002011745,0.00005366628,0.00002392294,0.00001784309,0.00003908667],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005187879,0.00002991068,0.0006050706,0.0000180685,0.000003896197,0.0002281715,0.000009539372,0.00006639905,0.9984387,0.00005241099,0.00005817079,0.0004377626],"study_design_scores_gemma":[0.00002094392,0.001218933,0.04322825,0.00001871713,0.00003604543,0.006069019,0.0002673324,0.003901732,0.9408069,0.0001562779,0.004240773,0.00003507627],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.995909,0.0002208789,0.001621336,0.000139404,0.0000214974,0.00003377388,0.0008661415,0.00006895183,0.001119099],"genre_scores_gemma":[0.9935129,0.0002619693,0.003263936,0.0001020635,0.00001409576,0.00003318096,0.001766184,0.00003480036,0.001010823],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001557186,"threshold_uncertainty_score":0.003096223,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009389895077389965,"score_gpt":0.2527539435604989,"score_spread":0.2433640484831089,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}