{"id":"W4411199491","doi":"10.1016/j.lanmic.2025.101126","title":"Efficacy, safety, pharmacokinetics, and associated microbiome changes of ibezapolstat compared with vancomycin in adults with Clostridioides difficile infection: a phase 2b, randomised, double-blind, active-controlled, multicentre study","year":2025,"lang":"en","type":"article","venue":"The Lancet Microbe","topic":"Clostridium difficile and Clostridium perfringens research","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Altasciences (Canada)","funders":"National Institute of Allergy and Infectious Diseases","keywords":"Clostridioides; Medicine; Vancomycin; Pharmacokinetics; Microbiome; Double blind; Double blind study; Internal medicine; Intensive care medicine; Anesthesia; Bioinformatics; Biology; Alternative medicine; Staphylococcus aureus","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0006727708,0.0004659466,0.001743701,0.0004428714,0.0001872558,0.00005621751,0.0002577871,0.0001180783,0.00006515377],"category_scores_gemma":[0.0001173481,0.000287165,0.0001149716,0.001223525,0.0003374508,0.00006004457,0.0001905204,0.0006840808,0.000004336605],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002687364,"about_ca_system_score_gemma":0.0002491146,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001100519,"about_ca_topic_score_gemma":0.004500496,"domain_scores_codex":[0.997354,0.0003453724,0.0006488849,0.0005808472,0.0003780426,0.0006928048],"domain_scores_gemma":[0.9979193,0.000690225,0.0003285309,0.0005605713,0.0003675453,0.0001338631],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.8482285,0.007078326,0.01158965,0.0004235526,0.001666244,0.0001040644,0.002828197,0.0001221482,0.1235797,0.000004846775,0.0007354333,0.003639283],"study_design_scores_gemma":[0.8149878,0.002066775,0.009234626,0.00142126,0.0009444762,0.00003585898,0.001709894,0.0003805405,0.1680346,0.000001023985,0.0008768086,0.0003063992],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9878328,0.001094364,0.00001778015,0.002141759,0.00008587317,0.008130218,0.0001720134,0.0000753433,0.0004497918],"genre_scores_gemma":[0.9977366,0.001119821,0.00004905048,0.000148934,0.0001451779,0.0002378645,0.0001333267,0.00004317913,0.0003860952],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04445482,"threshold_uncertainty_score":0.999958,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02946515561400125,"score_gpt":0.3336366434094372,"score_spread":0.304171487795436,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}