{"id":"W4411199491","doi":"10.1016/j.lanmic.2025.101126","title":"Efficacy, safety, pharmacokinetics, and associated microbiome changes of ibezapolstat compared with vancomycin in adults with Clostridioides difficile infection: a phase 2b, randomised, double-blind, active-controlled, multicentre study","year":2025,"lang":"en","type":"article","venue":"The Lancet Microbe","topic":"Clostridium difficile and Clostridium perfringens research","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Altasciences (Canada)","funders":"National Institute of Allergy and Infectious Diseases","keywords":"Clostridioides; Medicine; Vancomycin; Pharmacokinetics; Microbiome; Double blind; Double blind study; Internal medicine; Intensive care medicine; Anesthesia; Bioinformatics; Biology; Alternative medicine; Staphylococcus aureus","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003006602,0.00163097,0.003219031,0.0004576214,0.0005282611,0.001073729,0.0007747225,0.001930751,0.003989818],"category_scores_gemma":[0.002788616,0.0009701826,0.001788487,0.0004150601,0.001057516,0.001157575,0.000477965,0.002062929,0.0006492433],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000708038,"about_ca_system_score_gemma":0.001354413,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006204708,"about_ca_topic_score_gemma":0.001497872,"domain_scores_codex":[0.9986009,0.0007558684,0.0001471112,0.0002174662,0.0001251552,0.0001535586],"domain_scores_gemma":[0.9977759,0.000547499,0.0007036251,0.000141131,0.0002356957,0.0005960952],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9647853,0.01767697,0.001237144,0.0007613163,0.0006840676,0.00003444354,0.00009724689,0.0001665004,0.005035203,0.00002456433,0.0002456013,0.009251507],"study_design_scores_gemma":[0.6228062,0.3708756,0.004554917,0.0000450762,0.0005285891,0.00003428076,0.00004028769,0.0001826452,0.0005629512,0.00003521278,0.0003147998,0.00001950889],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.994547,0.002306988,0.00024804,0.0002096467,0.000144369,0.001849172,0.0003223423,0.00003163195,0.0003407351],"genre_scores_gemma":[0.9910286,0.001762575,0.001549396,0.0006177063,0.0002769655,0.003358665,0.0004167681,0.00001651862,0.0009728997],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003989818,"threshold_uncertainty_score":0.01590067,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02946515561400125,"score_gpt":0.3336366434094372,"score_spread":0.304171487795436,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}