{"id":"W4411202328","doi":"10.1016/j.jaccas.2025.103683","title":"Hydroxychloroquine Cardiotoxicity and Sarcomeric Hypertrophic Cardiomyopathy","year":2025,"lang":"en","type":"article","venue":"JACC Case Reports","topic":"Drug-Induced Ocular Toxicity","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Calgary Laboratory Services; University of Alberta; University of Calgary","funders":"","keywords":"Cardiotoxicity; Hydroxychloroquine; Hypertrophic cardiomyopathy; Medicine; Cardiomyopathy; Internal medicine; Cardiology; Heart failure; Coronavirus disease 2019 (COVID-19); Chemotherapy; Disease; Infectious disease (medical specialty)","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0006459078,0.0003042724,0.0008271998,0.0003156316,0.0001754262,0.00004203749,0.00003551182,0.0001933057,0.00002573313],"category_scores_gemma":[0.0004943817,0.0002768789,0.0002900398,0.0006035075,0.0001366121,0.0001065422,0.0001763181,0.000377407,0.00000777654],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002084206,"about_ca_system_score_gemma":0.0002325859,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000658187,"about_ca_topic_score_gemma":0.0000312238,"domain_scores_codex":[0.997813,0.00008424558,0.0005965577,0.0007151447,0.0003794562,0.0004116224],"domain_scores_gemma":[0.9982296,0.00006495578,0.0001644104,0.001098063,0.0001477194,0.0002952746],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"case_report","study_design_gemma":"case_report","study_design_scores_codex":[0.00008230524,0.0002380759,0.1489231,0.0004109373,0.0005617625,0.7717513,0.0001333304,0.00002809253,0.04632033,0.00007389207,0.00112963,0.03034723],"study_design_scores_gemma":[0.001706283,0.0001714791,0.1188609,0.0002783131,0.0009901341,0.8121353,0.0001608556,0.0004559442,0.02795319,0.0003971223,0.03632694,0.0005635867],"study_design_candidate":"case_report","study_design_consensus":"case_report","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9752801,0.002282683,0.0002521845,0.0006296522,0.000611419,0.0007026966,0.000006195195,0.0001966387,0.02003845],"genre_scores_gemma":[0.9969769,0.00008800286,0.0005144816,0.0006679738,0.0002287575,0.00004831371,0.00001444199,0.00003746837,0.001423716],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04038399,"threshold_uncertainty_score":0.9999683,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009675586961785457,"score_gpt":0.2689785274771987,"score_spread":0.2593029405154133,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}