{"id":"W4411203917","doi":"10.1021/acs.orglett.5c02163","title":"Optimized Radiosynthesis of the Ketone Body Radioligand (3<i>S</i>)-4-[<sup>18</sup>F]Fluoro-3-hydroxybutyric Acid ([<sup>18</sup>F]FBHB) for PET Imaging","year":2025,"lang":"en","type":"article","venue":"Organic Letters","topic":"Medical Imaging Techniques and Applications","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Natural Sciences and Engineering Research Council of Canada; University of Alberta","keywords":"Radiosynthesis; Radioligand; Chemistry; Ketone; Pet imaging; Radiochemistry; Positron emission tomography; Nuclear medicine; Organic chemistry; Receptor; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004198902,0.0007110744,0.0003604641,0.0002819644,0.000211019,0.0003490088,0.0004387496,0.0005345714,0.001366156],"category_scores_gemma":[0.0003277458,0.0001830888,0.0002300312,0.0002941394,0.0002831916,0.0003555354,0.0003070988,0.0005878141,0.0007850029],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004142569,"about_ca_system_score_gemma":0.0005373977,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001077371,"about_ca_topic_score_gemma":0.00206671,"domain_scores_codex":[0.9997974,0.0000416663,0.00001236441,0.00006210618,0.00004052434,0.00004591225],"domain_scores_gemma":[0.9998852,0.00002082506,0.00003159734,0.00001541574,0.00003056292,0.00001645785],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001865168,0.00003165807,0.000110957,0.0001518475,0.0000157287,0.0001707121,0.00005985372,0.001076849,0.9904701,0.0007052099,0.0002863107,0.006734209],"study_design_scores_gemma":[0.00002066162,0.0002420543,0.0002263019,0.000006426239,0.00001483059,0.0001805026,0.00001919066,0.001139108,0.9931656,0.0001054058,0.004863553,0.00001635929],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8279563,0.006588733,0.14936,0.0003538839,0.0002440442,0.00039676,0.001457014,0.0007852186,0.01285806],"genre_scores_gemma":[0.9146699,0.003490034,0.07577159,0.0001733323,0.00004008813,0.0002128988,0.001057991,0.000200834,0.004383259],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001366156,"threshold_uncertainty_score":0.004570305,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009735964521074331,"score_gpt":0.2621071359437178,"score_spread":0.2523711714226434,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}