{"id":"W4411204376","doi":"10.2337/db24-1122","title":"Autoreactive T Cells and Cytokine Stress Drive β-Cell Senescence Entry and Accumulation in Type 1 Diabetes","year":2025,"lang":"en","type":"article","venue":"Diabetes","topic":"Diabetes and associated disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba; Children's Hospital Research Institute of Manitoba","funders":"Institute of Nutrition, Metabolism and Diabetes; National Institute of Diabetes and Digestive and Kidney Diseases; National Institutes of Health; University of Alberta; Natural Sciences and Engineering Research Council of Canada; Manitoba Medical Service Foundation; Research Manitoba; Beckman Research Institute, City of Hope","keywords":"Senescence; Cytokine; Immunology; Cell biology; Diabetes mellitus; Biology; Type 2 diabetes; Medicine; Endocrinology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001533422,0.000404781,0.0002918299,0.0002921266,0.0001698847,0.0002619986,0.000152605,0.0003373348,0.001274042],"category_scores_gemma":[0.0001155312,0.0001888059,0.0003305707,0.0001501538,0.0002359429,0.0002349637,0.0002796247,0.001095148,0.0003219426],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001728187,"about_ca_system_score_gemma":0.0001344496,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001643159,"about_ca_topic_score_gemma":0.0002514266,"domain_scores_codex":[0.9998676,0.00002317853,0.00001789486,0.00003507054,0.00002249881,0.00003379539],"domain_scores_gemma":[0.9998579,0.00001839724,0.00004250072,0.00001419789,0.00001261135,0.00005433157],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0002758574,0.00006552199,0.000519095,0.00003469855,0.00000294271,0.00005744009,0.00001960117,0.00002715608,0.997901,0.00003972662,0.00002200479,0.001034972],"study_design_scores_gemma":[0.0002065993,0.002943873,0.0701885,0.00005758236,0.0000805895,0.001594412,0.0001969282,0.001617177,0.9184453,0.0004370997,0.004209619,0.00002221849],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.996606,0.001633954,0.0007806407,0.00005850959,0.00003399023,0.00001771804,0.0001003734,0.00004571688,0.000723003],"genre_scores_gemma":[0.9951845,0.001770184,0.001137677,0.00014628,0.00005308747,0.00004885599,0.000183458,0.00002321291,0.001452757],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001274042,"threshold_uncertainty_score":0.00426209,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004421155666473796,"score_gpt":0.2277436801623651,"score_spread":0.2233225244958913,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}