{"id":"W4411207568","doi":"10.1073/pnas.2411724122","title":"Keratinocyte–TRPV1 sensory neuron interactions in a genetically controllable mouse model of chronic neuropathic itch","year":2025,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Dermatology and Skin Diseases","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Clinical Research Institute","funders":"National Institute of Arthritis and Musculoskeletal and Skin Diseases; National Institute of Neurological Disorders and Stroke; Sandler Foundation; Canadian Institutes of Health Research; University of California, San Francisco; National Institute of Dental and Craniofacial Research; Open Philanthropy Project; National Science Foundation","keywords":"TRPV1; Sensory neuron; Neuropathic pain; Sensory system; Neuroscience; Neuron; Medicine; Biology; Transient receptor potential channel; Receptor; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003589997,0.0007950111,0.0004066559,0.0009486792,0.0003653186,0.0004909633,0.0004205337,0.0006866392,0.002131728],"category_scores_gemma":[0.000154362,0.0003624525,0.0003884912,0.0002789704,0.000822863,0.0005866757,0.0003328869,0.001499676,0.0004118848],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004969024,"about_ca_system_score_gemma":0.0003833144,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008284489,"about_ca_topic_score_gemma":0.002118717,"domain_scores_codex":[0.9996052,0.00006904398,0.00005132474,0.00009528715,0.00009011133,0.00008895191],"domain_scores_gemma":[0.9997053,0.00003562574,0.00009484607,0.00004081076,0.00001841388,0.0001049152],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003263817,0.000327792,0.000203195,0.00005655256,0.000009792857,0.0002232115,0.00004397035,0.0001487397,0.9972325,0.0003256591,0.00007888817,0.001023451],"study_design_scores_gemma":[0.0004121753,0.005107265,0.008453368,0.0001070223,0.0001142747,0.002823974,0.0002805293,0.00474948,0.9724932,0.0004795208,0.004947842,0.00003130816],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9939242,0.0006370691,0.003263469,0.0001746705,0.00007067455,0.0001102818,0.0005288206,0.0001884874,0.001102442],"genre_scores_gemma":[0.9888621,0.0008703807,0.00388529,0.00009526139,0.00001930197,0.0002395643,0.0005133566,0.00005987681,0.005454825],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002131728,"threshold_uncertainty_score":0.007131338,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04190873689488412,"score_gpt":0.3306259590554455,"score_spread":0.2887172221605614,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}