{"id":"W4411210281","doi":"10.1093/nar/gkaf512","title":"<i>R</i>-2-hydroxyglutarate-mediated inhibition of KDM4A compromises telomere integrity","year":2025,"lang":"en","type":"article","venue":"Nucleic Acids Research","topic":"Telomeres, Telomerase, and Senescence","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre; McGill University; Occupational Cancer Research Centre; Centre Hospitalier Universitaire Sainte-Justine; Université de Montréal; Hôpital Maisonneuve-Rosemont","funders":"Natural Sciences and Engineering Research Council of Canada; Terry Fox Foundation; Canada Foundation for Innovation; Fonds de Recherche du Québec - Santé; Cole Foundation; Fondation de l’Hôpital Maisonneuve-Rosemont; McGill University; Canadian Institutes of Health Research; Cancer Research Society; Chesapeake Research Consortium","keywords":"Biology; Telomere; Genetics; Cell biology; DNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001551416,0.0004002797,0.00034833,0.0001632756,0.0001471818,0.0002004287,0.0003696941,0.0002726202,0.001262124],"category_scores_gemma":[0.00009941356,0.000144915,0.000356823,0.0001722648,0.0002315936,0.0001548143,0.0001968739,0.0005481171,0.0004838053],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003158224,"about_ca_system_score_gemma":0.0001901377,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006454265,"about_ca_topic_score_gemma":0.0007626303,"domain_scores_codex":[0.9998197,0.00002908686,0.00002654538,0.0000368203,0.00003887066,0.000048952],"domain_scores_gemma":[0.9999017,0.00001550271,0.00003390485,0.00001981011,0.000007031465,0.00002216486],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000136709,0.00002841944,0.00006110207,0.00003092377,0.000008787559,0.00003580282,0.000006278317,0.0000490749,0.9988393,0.00006859862,0.00005805711,0.0006770454],"study_design_scores_gemma":[0.00001265599,0.0002025648,0.0008830897,0.000002039414,0.00000716206,0.0001020342,0.000006123681,0.000350045,0.9966623,0.00001917696,0.001750698,0.000002196127],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9898637,0.002735279,0.00312358,0.0002154281,0.00009604705,0.00005665441,0.0008785799,0.0003338751,0.002696952],"genre_scores_gemma":[0.9941078,0.0008052199,0.00191637,0.00008337762,0.00001304864,0.0000535833,0.0008508873,0.00003841112,0.002131211],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001262124,"threshold_uncertainty_score":0.004222214,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05772176344805448,"score_gpt":0.3689099272531529,"score_spread":0.3111881638050984,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}