{"id":"W4411213104","doi":"10.21203/rs.3.rs-6824809/v1","title":"Quinoline-6-Carboxylic Acid Derivatives: A New Class of Potent Ectonucleotidase Inhibitors","year":2025,"lang":"en","type":"preprint","venue":"Research Square","topic":"Adenosine and Purinergic Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université Laval","funders":"Deanship of Scientific Research, King Saud University; Natural Sciences and Engineering Research Council of Canada; Higher Education Commision, Pakistan; King Saud University","keywords":"Quinoline; Chemistry; Carboxylic acid; Class (philosophy); Pharmacology; Combinatorial chemistry; Biochemistry; Stereochemistry; Organic chemistry; Medicine; Computer science","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002609352,0.0003867504,0.0003658332,0.0002828594,0.0001691107,0.0003440075,0.000416451,0.0003375307,0.002431968],"category_scores_gemma":[0.0001435186,0.0001083512,0.0001762599,0.0002147933,0.0001779894,0.0002858232,0.0002412464,0.0006407855,0.001000581],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002122805,"about_ca_system_score_gemma":0.0001522032,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000253805,"about_ca_topic_score_gemma":0.0005753789,"domain_scores_codex":[0.9999298,0.00001393971,0.00000406215,0.0000184914,0.00001736492,0.00001631851],"domain_scores_gemma":[0.999941,0.00001093214,0.00001171882,0.000005979395,0.00001029727,0.0000201933],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000972971,0.0001993917,0.0002573307,0.0007002449,0.00004194599,0.0006524411,0.0001231377,0.002052877,0.8482874,0.01001509,0.0058718,0.1308253],"study_design_scores_gemma":[0.0009317914,0.005906595,0.003838976,0.0001677382,0.0001640164,0.003501212,0.00007291446,0.004585502,0.5721666,0.003906811,0.4046328,0.0001250574],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.5320001,0.3040491,0.0846576,0.003566915,0.0015828,0.0005506596,0.002794025,0.001203613,0.06959522],"genre_scores_gemma":[0.8693528,0.08282842,0.01822297,0.0009768947,0.0004240773,0.0002398467,0.001505769,0.00008962861,0.02635956],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002431968,"threshold_uncertainty_score":0.008135736,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04133943464512449,"score_gpt":0.365662039343166,"score_spread":0.3243226046980415,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}