{"id":"W4411218663","doi":"10.1002/alz.70318","title":"Epigenome‐wide association study of cerebrospinal fluid–based biomarkers of Alzheimer's disease in cognitively normal individuals","year":2025,"lang":"en","type":"article","venue":"Alzheimer s & Dementia","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Children's Hospital; University of British Columbia","funders":"National Institute on Aging; Goizueta Business School, Emory University; Emory University; U.S. Department of Veterans Affairs","keywords":"Epigenome; Cerebrospinal fluid; Disease; Association (psychology); Medicine; Alzheimer's disease; Pathology; Neuroscience; Psychology; Biology; Genetics; DNA methylation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001268905,0.0004013341,0.0007414508,0.001283419,0.0004670653,0.0006822948,0.0004916989,0.0005992213,0.001814134],"category_scores_gemma":[0.00331229,0.000243164,0.001169685,0.002850078,0.0003103909,0.0003743107,0.0006094772,0.0005367952,0.0001783963],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004208269,"about_ca_system_score_gemma":0.0004623906,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01242663,"about_ca_topic_score_gemma":0.0161328,"domain_scores_codex":[0.9986178,0.0004287571,0.0001200073,0.0005725059,0.0001480315,0.0001130366],"domain_scores_gemma":[0.998647,0.0004078003,0.0003829468,0.0002251552,0.0002032562,0.0001338789],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0008875567,0.00003755368,0.9753931,0.0003444366,0.008225546,0.0002009696,0.0001618484,0.0003464479,0.002247953,0.0002502572,0.001323496,0.01058078],"study_design_scores_gemma":[0.00003815535,0.00006387797,0.9955799,0.00005625401,0.001787366,0.0001582816,0.00006916952,0.000234929,0.0002286177,0.0002959431,0.001479429,0.000008137762],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9736984,0.01305424,0.001501182,0.0005485418,0.000077233,0.0000379621,0.009399955,0.00004588222,0.001636704],"genre_scores_gemma":[0.9938952,0.00182358,0.0006921732,0.0002456695,0.00004173652,0.00006347536,0.002829612,0.0000137966,0.0003948195],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01242663,"threshold_uncertainty_score":0.02470857,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01470068975366236,"score_gpt":0.2773271157107801,"score_spread":0.2626264259571177,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}