{"id":"W4411223753","doi":"10.1007/s12325-025-03226-3","title":"Sustained Effectiveness, Tolerability, and Safety of Long-Term Prophylaxis with Lanadelumab in Hereditary Angioedema: The Prospective, Phase 4, Noninterventional EMPOWER Real-World Study","year":2025,"lang":"en","type":"article","venue":"Advances in Therapy","topic":"Coagulation, Bradykinin, Polyphosphates, and Angioedema","field":"Medicine","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Sanofi Genzyme; Grifols; BioCryst; Regeneron Pharmaceuticals; Moderna; Takeda Pharmaceuticals U.S.A.; BioMarin Pharmaceutical; AstraZeneca; CSL Behring; Amgen; Sanofi; GlaxoSmithKline","keywords":"Medicine; Tolerability; Hereditary angioedema; Angioedema; Rheumatology; Internal medicine; Adverse effect; Intensive care medicine; Physical therapy; Dermatology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003420937,0.0007100506,0.0007677001,0.0002167488,0.0003515141,0.001017878,0.0004930637,0.0006227162,0.002389466],"category_scores_gemma":[0.001958789,0.0003317113,0.0009584324,0.0002407096,0.0007020045,0.0007598407,0.0004055632,0.001617586,0.0005503212],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006555502,"about_ca_system_score_gemma":0.0008372682,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007662497,"about_ca_topic_score_gemma":0.001625151,"domain_scores_codex":[0.9989151,0.0006125483,0.00006663111,0.0001260004,0.0001557729,0.0001238892],"domain_scores_gemma":[0.9978595,0.0003996837,0.000861304,0.0001925471,0.0001969405,0.0004898584],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"observational","study_design_scores_codex":[0.7191158,0.05765835,0.1410935,0.0008070771,0.003577079,0.0002532712,0.0004927695,0.001248439,0.01076044,0.0001315857,0.003210103,0.06165164],"study_design_scores_gemma":[0.278284,0.4637192,0.2476753,0.0000995395,0.001819083,0.0007187577,0.0002294181,0.001165826,0.003084625,0.0001691629,0.002966219,0.00006888984],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9972495,0.0007804199,0.0001291536,0.00006745204,0.00001153044,0.0004762824,0.000612632,0.00001986172,0.000652976],"genre_scores_gemma":[0.9969534,0.0003944222,0.0003845025,0.0001739626,0.00004751535,0.0005194329,0.0009976327,0.000005047335,0.0005239592],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003420937,"threshold_uncertainty_score":0.01809186,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009382766756255299,"score_gpt":0.3389247064883207,"score_spread":0.3295419397320654,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}