{"id":"W4411223753","doi":"10.1007/s12325-025-03226-3","title":"Sustained Effectiveness, Tolerability, and Safety of Long-Term Prophylaxis with Lanadelumab in Hereditary Angioedema: The Prospective, Phase 4, Noninterventional EMPOWER Real-World Study","year":2025,"lang":"en","type":"article","venue":"Advances in Therapy","topic":"Coagulation, Bradykinin, Polyphosphates, and Angioedema","field":"Medicine","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Sanofi Genzyme; Grifols; BioCryst; Regeneron Pharmaceuticals; Moderna; Takeda Pharmaceuticals U.S.A.; BioMarin Pharmaceutical; AstraZeneca; CSL Behring; Amgen; Sanofi; GlaxoSmithKline","keywords":"Medicine; Tolerability; Hereditary angioedema; Angioedema; Rheumatology; Internal medicine; Adverse effect; Intensive care medicine; Physical therapy; Dermatology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006079765,0.0002023294,0.0004988566,0.0002189696,0.0000762964,0.00001274032,0.0001154243,0.00004515746,0.00004493672],"category_scores_gemma":[0.0000391151,0.000130987,0.00007994781,0.0007020654,0.0002663702,0.0002247259,0.00005202141,0.0001778641,2.468512e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001595961,"about_ca_system_score_gemma":0.0001439935,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004479403,"about_ca_topic_score_gemma":0.007146957,"domain_scores_codex":[0.9984971,0.0002044225,0.0004591238,0.0003904109,0.0002360789,0.0002128345],"domain_scores_gemma":[0.9990609,0.0003421734,0.0001210463,0.0003071492,0.0001333101,0.00003538808],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.008295837,0.002328167,0.9517012,0.0002264208,0.0001320087,0.000071122,0.0008549673,0.00005201901,0.0000447728,0.0006570742,0.000003120347,0.03563336],"study_design_scores_gemma":[0.01465617,0.00261422,0.9789051,0.0005594061,0.00002688215,0.000007306884,0.0005640622,0.00004190178,0.000618043,0.001834104,0.00005019699,0.0001226288],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9865524,0.00951984,0.0001640683,0.0002465827,0.0001159356,0.002586372,0.00001053058,0.00002521515,0.0007790503],"genre_scores_gemma":[0.9987265,0.0006204543,0.00005894766,0.00004270099,0.00004378397,0.0001877725,0.00001760031,0.00001597546,0.0002862535],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03551073,"threshold_uncertainty_score":0.5341495,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009382766756255299,"score_gpt":0.3389247064883207,"score_spread":0.3295419397320654,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}