{"id":"W4411227150","doi":"10.1097/01.tp.0001123164.87708.16","title":"10-2: GENERATING AMYLOID RESISTANT STEM CELL-DERIVED BETA CELLS TO IMPROVE ISLET TRANSPLANT OUTCOMES IN TYPE 1 DIABETES","year":2025,"lang":"en","type":"article","venue":"Transplantation","topic":"Pancreatic function and diabetes","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Children's Hospital; University of British Columbia","funders":"","keywords":"Islet; Beta cell; BETA (programming language); Amyloid (mycology); Medicine; Stem cell; Type 1 diabetes; Diabetes mellitus; Type 2 diabetes; Internal medicine; Transplantation; Oncology; Cancer research; Endocrinology; Biology; Pathology; Cell biology; Computer science","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000379863,0.0004270408,0.0003563337,0.0002896462,0.0001495303,0.0006465415,0.0004166921,0.0006098828,0.004355717],"category_scores_gemma":[0.0001491567,0.0001378643,0.0003759373,0.0002037127,0.0002240929,0.0002878337,0.00029931,0.001106651,0.001123197],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002202331,"about_ca_system_score_gemma":0.0003024107,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003001742,"about_ca_topic_score_gemma":0.0004419239,"domain_scores_codex":[0.9998426,0.00001396855,0.00001409799,0.00003524831,0.00006344618,0.00003060523],"domain_scores_gemma":[0.9998689,0.00001478933,0.00003608887,0.00001335022,0.00001817905,0.00004866343],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004317668,0.0004611682,0.0008562823,0.0001878256,0.00002913419,0.0001411284,0.00007049362,0.0004002318,0.9847478,0.000311986,0.0007178934,0.01164426],"study_design_scores_gemma":[0.0002975773,0.003196276,0.005601462,0.00006885712,0.000147908,0.0009742521,0.00008450917,0.002222365,0.9696107,0.0002063647,0.01756614,0.00002365725],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9698675,0.002384959,0.01601052,0.0004470683,0.0003517882,0.0004477695,0.002145842,0.000740171,0.007604203],"genre_scores_gemma":[0.9642159,0.002692528,0.01512043,0.0003872368,0.00007115236,0.00045751,0.003066187,0.0001907468,0.0137983],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004355717,"threshold_uncertainty_score":0.01457137,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01115197728374468,"score_gpt":0.2397801156955137,"score_spread":0.228628138411769,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}