{"id":"W4411238360","doi":"10.1016/j.ccell.2025.05.013","title":"CSF1R+ myeloid-monocytic cells drive CAR-T cell resistance in aggressive B cell lymphoma","year":2025,"lang":"en","type":"article","venue":"Cancer Cell","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Horizon 2020; European Research Council; Hector Stiftung; Ministerium für Kultur und Wissenschaft des Landes Nordrhein-Westfalen; José Carreras Leukämie-Stiftung; Bundesministerium für Bildung und Forschung; Horizon 2020 Framework Programme; Imhoff Stiftung; Else Kröner-Fresenius-Stiftung; Bayerische Forschungsstiftung; Deutsche Forschungsgemeinschaft; Fritz-Bender-Stiftung; Deutsche Krebshilfe; Wilhelm Sander-Stiftung; Universität zu Köln; European Commission; Deutsches Zentrum für Infektionsforschung","keywords":"Lymphoma; Myeloid; Cancer research; Myeloid cells; Cell; Biology; Immunology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0003552739,0.0004901498,0.0008018841,0.000373543,0.0001303235,0.00006697325,0.0005303881,0.0003298792,0.002108515],"category_scores_gemma":[0.00004080867,0.0004892529,0.0002694257,0.001091805,0.0002480138,0.0001284457,0.0002046532,0.000524993,0.0002328465],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002956906,"about_ca_system_score_gemma":0.00189657,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001728107,"about_ca_topic_score_gemma":0.002065461,"domain_scores_codex":[0.9963474,0.0001761981,0.0007104428,0.001065563,0.000633757,0.0010667],"domain_scores_gemma":[0.9975296,0.0003383585,0.0003163679,0.001183555,0.000285612,0.0003465094],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.004031897,0.001263343,0.003056385,0.002444443,0.000111692,0.001360276,0.003838734,0.0002104986,0.9005429,0.00007481809,0.06839947,0.01466561],"study_design_scores_gemma":[0.01167981,0.0001630608,0.001852322,0.0006434144,0.0001162192,0.000002587238,0.0008910608,0.0002141113,0.7737527,0.0001682062,0.2100742,0.0004423282],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"other","genre_gemma":"empirical","genre_scores_codex":[0.4660796,0.0390393,0.00005464723,0.0007441431,0.00103898,0.001549967,0.000101355,0.0001129746,0.4912791],"genre_scores_gemma":[0.6688944,0.008241659,0.0003708322,0.0009882881,0.0002499515,0.0002427254,0.00003005551,0.00008276097,0.3208993],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.2028148,"threshold_uncertainty_score":0.9997559,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0135611302673057,"score_gpt":0.300678872634128,"score_spread":0.2871177423668222,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}