{"id":"W4411238360","doi":"10.1016/j.ccell.2025.05.013","title":"CSF1R+ myeloid-monocytic cells drive CAR-T cell resistance in aggressive B cell lymphoma","year":2025,"lang":"en","type":"article","venue":"Cancer Cell","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Horizon 2020; European Research Council; Hector Stiftung; Ministerium für Kultur und Wissenschaft des Landes Nordrhein-Westfalen; José Carreras Leukämie-Stiftung; Bundesministerium für Bildung und Forschung; Horizon 2020 Framework Programme; Imhoff Stiftung; Else Kröner-Fresenius-Stiftung; Bayerische Forschungsstiftung; Deutsche Forschungsgemeinschaft; Fritz-Bender-Stiftung; Deutsche Krebshilfe; Wilhelm Sander-Stiftung; Universität zu Köln; European Commission; Deutsches Zentrum für Infektionsforschung","keywords":"Lymphoma; Myeloid; Cancer research; Myeloid cells; Cell; Biology; Immunology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001464364,0.0001274595,0.0001785059,0.0002630469,0.0001454931,0.0003269301,0.00008241546,0.0001643813,0.001070315],"category_scores_gemma":[0.0001190126,0.0001067783,0.00009937839,0.0001434002,0.000172304,0.00010172,0.0001519733,0.0003205928,0.0002849281],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001816885,"about_ca_system_score_gemma":0.0001433086,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006344861,"about_ca_topic_score_gemma":0.001059068,"domain_scores_codex":[0.9998999,0.00002439722,0.00000707635,0.00001660233,0.00002331305,0.00002874591],"domain_scores_gemma":[0.9999422,0.00001280087,0.00001461226,0.000009243547,0.000004794931,0.00001637131],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002474028,0.00008962286,0.006464321,0.00002848989,0.000008722086,0.0002232461,0.00006484069,0.0001565158,0.9864969,0.0002009967,0.0001237797,0.005895216],"study_design_scores_gemma":[0.0001908355,0.002752228,0.1429873,0.00001917534,0.00008866214,0.004696249,0.0002964483,0.006109359,0.8331994,0.0004991611,0.009147772,0.00001336147],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.998276,0.0004290399,0.0006721428,0.00002435342,0.000001391538,0.0000205964,0.00009303648,0.00004732641,0.000436026],"genre_scores_gemma":[0.9986812,0.0001504776,0.0005569729,0.00002253817,0.000003173369,0.00001457443,0.000142044,0.000004800705,0.0004241222],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001070315,"threshold_uncertainty_score":0.00358057,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0135611302673057,"score_gpt":0.300678872634128,"score_spread":0.2871177423668222,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}