{"id":"W4411238671","doi":"10.1093/toxsci/kfaf085","title":"Leveraging toxicogenomics in a weight of evidence approach to demonstrate a CAR-mediated mode of action for cyclobutrifluram-related mouse liver tumors","year":2025,"lang":"en","type":"article","venue":"Toxicological Sciences","topic":"Cancer, Stress, Anesthesia, and Immune Response","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Syngenta (Canada)","funders":"Syngenta International","keywords":"Toxicogenomics; Mode of action; Action (physics); Computational biology; Biology; Cancer research; Toxicology; Bioinformatics; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00075331,0.0001458952,0.0004870301,0.0003161241,0.00008894005,0.00001550814,0.0002639084,0.0001470616,0.00001784834],"category_scores_gemma":[0.0009523891,0.00009884993,0.0001197121,0.001151793,0.0004779218,0.0001208844,0.00005506402,0.000149598,0.000001544669],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001620117,"about_ca_system_score_gemma":0.0004442222,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002400971,"about_ca_topic_score_gemma":0.00003514061,"domain_scores_codex":[0.9983975,0.0001231714,0.00051591,0.0003850614,0.0002489269,0.0003294703],"domain_scores_gemma":[0.9988552,0.0006405502,0.0001612043,0.0001586731,0.00009219798,0.0000921665],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.004097612,0.001150089,0.02894015,0.0004358998,0.00005981118,0.00001405204,0.001443009,0.005340183,0.9317372,0.0008056344,0.0002100142,0.02576635],"study_design_scores_gemma":[0.003728576,0.0038657,0.1881312,0.001523336,0.0001784436,0.0000757543,0.002991735,0.09076405,0.7067814,0.0006126005,0.0008134088,0.0005338498],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9962928,0.0008463039,0.000610091,0.0005844586,0.00006952813,0.0009247172,0.000007682666,0.00002940515,0.0006349643],"genre_scores_gemma":[0.9968855,0.0004466308,0.002102015,0.0001695123,0.00002259722,0.0000813873,0.000002813091,0.000004635763,0.000284862],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2249558,"threshold_uncertainty_score":0.4030983,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1228869856378724,"score_gpt":0.3573247102338048,"score_spread":0.2344377245959324,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}