{"id":"W4411241237","doi":"10.1093/procel/pwaf047","title":"RNA G-quadruplex (rG4) exacerbates cellular senescence by mediating ribosome pausing","year":2025,"lang":"en","type":"article","venue":"Protein & Cell","topic":"Viral Infections and Immunology Research","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Aging","funders":"Science and Technology Planning Project of Guangdong Province; National Key Research and Development Program of China; Guangdong Provincial People's Hospital; National Natural Science Foundation of China","keywords":"G-quadruplex; Senescence; Telomere; Biology; RNA; Cell biology; Developmental biology; Genetics; Ribosome; Molecular biology; DNA; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001566739,0.0003131444,0.0002435793,0.0002975846,0.0001134951,0.0001944846,0.0001343126,0.0002677574,0.001171445],"category_scores_gemma":[0.0001136075,0.0001050873,0.0002295141,0.00007813748,0.0001809344,0.0001400965,0.0001935783,0.000327196,0.0002410783],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002133324,"about_ca_system_score_gemma":0.0001350378,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002146692,"about_ca_topic_score_gemma":0.000428606,"domain_scores_codex":[0.9998823,0.00002628916,0.00001145131,0.00002844706,0.00002516513,0.00002635649],"domain_scores_gemma":[0.9998769,0.00001494995,0.00005868662,0.000009625569,0.00001177118,0.00002806341],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005114682,0.000008958327,0.0001567913,0.00001906341,0.00000515655,0.00001806247,0.000004071293,0.0000257681,0.9990951,0.00002892418,0.00001728841,0.0005697602],"study_design_scores_gemma":[0.000010155,0.0006295328,0.007398116,0.000007402505,0.00002372213,0.0001741807,0.00002405231,0.0008578826,0.9890541,0.00009368256,0.001721802,0.000005400321],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9946037,0.001501618,0.002829553,0.00009018494,0.0000321438,0.00002409641,0.000252114,0.000138252,0.0005283869],"genre_scores_gemma":[0.9946149,0.0006222048,0.002646689,0.00009862715,0.0000186487,0.00002474677,0.0004222592,0.0000247822,0.001527158],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001171445,"threshold_uncertainty_score":0.003918886,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009232129075782507,"score_gpt":0.2760698267135603,"score_spread":0.2668376976377778,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}