{"id":"W4411244435","doi":"10.1093/nar/gkaf511","title":"Unraveling the regulatory dynamics of bidirectional promoters for modulating gene co-expression and metabolic flux in <i>Saccharomyces cerevisiae</i>","year":2025,"lang":"en","type":"article","venue":"Nucleic Acids Research","topic":"Plant biochemistry and biosynthesis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre; University of British Columbia; McGill University","funders":"Fonds de recherche du Québec – Nature et technologies; Fonds de Recherche du Québec - Santé; Natural Sciences and Engineering Research Council of Canada; Mitacs; Canadian Institutes of Health Research; Alliance de recherche numérique du Canada; Michael Smith Health Research BC; McGill University","keywords":"Biology; Saccharomyces cerevisiae; Promoter; Gene expression; Gene; Regulation of gene expression; Flux (metallurgy); Genetics; Cell biology; Computational biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002565579,0.0002897186,0.000292714,0.0001537992,0.0001250921,0.0003450387,0.0002491955,0.0001681391,0.0006019963],"category_scores_gemma":[0.0003370048,0.0001758876,0.0002857088,0.0001708676,0.0001900919,0.0002380199,0.0002619784,0.0005242742,0.0003126188],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000285229,"about_ca_system_score_gemma":0.0004118114,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009123468,"about_ca_topic_score_gemma":0.002128384,"domain_scores_codex":[0.9999089,0.00001249839,0.00000773579,0.00002850539,0.00003070356,0.00001159387],"domain_scores_gemma":[0.9998565,0.00004679368,0.00004344526,0.00001611034,0.0000191693,0.00001799754],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009088236,0.00001274704,0.001424052,0.0001093859,0.000008061563,0.00003884161,0.00002547247,0.001363021,0.9867834,0.0005590395,0.0000398514,0.00954515],"study_design_scores_gemma":[0.00001441405,0.0001571459,0.00421759,0.00002798025,0.00005067372,0.0002373796,0.00008200922,0.01854737,0.9680778,0.0006602043,0.007908795,0.00001875201],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8981233,0.003223997,0.09545492,0.0001341726,0.00003701289,0.00006343272,0.0007562512,0.0005409112,0.001665998],"genre_scores_gemma":[0.9491201,0.001510955,0.04757313,0.0000424295,0.000007526692,0.0000375864,0.0008777933,0.00009869398,0.0007317574],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009123468,"threshold_uncertainty_score":0.002069473,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02156493030512889,"score_gpt":0.3131664996577008,"score_spread":0.2916015693525719,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}