{"id":"W4411247747","doi":"10.1136/jnnp-2025-335831","title":"Blood biomarkers for predicting disability worsening in progressive multiple sclerosis: a multinational, individual participant-level analysis","year":2025,"lang":"en","type":"article","venue":"Journal of Neurology Neurosurgery & Psychiatry","topic":"Multiple Sclerosis Research Studies","field":"Medicine","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital; McGill University Health Centre; Montreal Neurological Institute and Hospital","funders":"National Institute of Neurological Disorders and Stroke","keywords":"Multinational corporation; Multiple sclerosis; Medicine; Psychology; Psychiatry; Political science","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01468675,0.0008851751,0.00126095,0.0009073755,0.0006854936,0.001151405,0.0009859293,0.0009131165,0.001122253],"category_scores_gemma":[0.01011174,0.0005276969,0.003266906,0.001851913,0.0003526056,0.0007275032,0.001628768,0.0008169261,0.0002160837],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005006992,"about_ca_system_score_gemma":0.000805124,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.006905316,"about_ca_topic_score_gemma":0.008788578,"domain_scores_codex":[0.9946271,0.003280172,0.0003367013,0.00108743,0.0004460955,0.0002225717],"domain_scores_gemma":[0.9926361,0.002398693,0.002434817,0.001475046,0.0006551835,0.0004001888],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00210574,0.00004627068,0.9916124,0.00006247844,0.00311537,0.00003259063,0.0000902689,0.0002237851,0.0001895058,0.00001350863,0.0001713223,0.002336725],"study_design_scores_gemma":[0.000182404,0.0007287294,0.993193,0.00003627106,0.003240125,0.0001284892,0.0001303052,0.001701496,0.000129151,0.00004173973,0.0004725834,0.00001575123],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9959452,0.0009610565,0.0008015578,0.00004853487,0.00001644906,0.00005949169,0.00194924,0.00001905713,0.0001994571],"genre_scores_gemma":[0.9969983,0.0001917436,0.0009876336,0.0000367585,0.00001288289,0.0001635987,0.001430847,0.000009970718,0.0001682483],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01468675,"threshold_uncertainty_score":0.07767189,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.120213149355994,"score_gpt":0.3556667527670305,"score_spread":0.2354536034110365,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}