{"id":"W4411251023","doi":"10.1016/j.jagp.2025.06.008","title":"Preliminary Investigation of the Association Between Epigenetic Aging Acceleration and Amyloid Biomarkers in Bipolar Disorder","year":2025,"lang":"en","type":"article","venue":"American Journal of Geriatric Psychiatry","topic":"Bipolar Disorder and Treatment","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":false,"ca_institutions":"Douglas Mental Health University Institute","funders":"National Institute on Aging; National Institutes of Health; National Institute of Mental Health; University of Texas Health Science Center at Houston; John S. Dunn Foundation; Texas Alzheimer's Research and Care Consortium; Glaucoma Research Foundation; Milken Institute","keywords":"Epigenetics; Bipolar disorder; Association (psychology); Amyloid (mycology); Medicine; Acceleration; Oncology; Psychology; Clinical psychology; Biology; Genetics; Mood; Pathology; Physics; Psychotherapist","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006268976,0.0003042789,0.0002525469,0.0004615606,0.000465331,0.0006254462,0.0001911953,0.0003477411,0.002514052],"category_scores_gemma":[0.001781233,0.0001801655,0.0003066626,0.0004456377,0.0001871908,0.0002546893,0.0002424863,0.0004977745,0.0002009346],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002490047,"about_ca_system_score_gemma":0.0002803465,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002434474,"about_ca_topic_score_gemma":0.004075304,"domain_scores_codex":[0.9998513,0.00004514653,0.00001964188,0.00003237521,0.00002770123,0.00002380237],"domain_scores_gemma":[0.9992718,0.0002109078,0.0002219831,0.00006469835,0.0001315732,0.00009907741],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00333439,0.0002908874,0.9561325,0.000121396,0.0003025968,0.0009965521,0.0004409312,0.00007876639,0.0166339,0.0002386037,0.0003864323,0.02104309],"study_design_scores_gemma":[0.00002011269,0.0004672192,0.9971108,0.00001184435,0.0001310686,0.0004940876,0.0001574683,0.00007042241,0.0007392142,0.0001878064,0.0006060048,0.000003857371],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9956928,0.001646369,0.0002703967,0.0002191434,0.00003706462,0.00002120271,0.0004071173,0.000008116425,0.00169777],"genre_scores_gemma":[0.9979153,0.0005659065,0.0004237992,0.0001336652,0.00004760004,0.00001627322,0.000212571,0.000003206606,0.0006817893],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002514052,"threshold_uncertainty_score":0.008410394,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005683392081239502,"score_gpt":0.2476257067447259,"score_spread":0.2419423146634865,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}