{"id":"W4411251546","doi":"10.1016/j.cej.2025.164764","title":"Surface engineering of copper peroxide nanodots and Au nanozyme on porphyrin-based metal-organic frameworks induces cascade reactions for colorectal cancer treatment","year":2025,"lang":"en","type":"article","venue":"Chemical Engineering Journal","topic":"Nanoplatforms for cancer theranostics","field":"Engineering","cited_by":18,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Waterloo","funders":"Science and Technology Program of Hubei Province; Hubei University of Science and Technology; Hunan Provincial Science and Technology Department; National Natural Science Foundation of China","keywords":"Porphyrin; Copper; Peroxide; Nanodot; Metal-organic framework; Colorectal cancer; Cascade; Chemistry; Photochemistry; Cancer research; Materials science; Cancer; Nanotechnology; Medicine; Internal medicine; Organic chemistry; Adsorption","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00005393723,0.0001997287,0.0001056533,0.00007942556,0.00008025734,0.0001422474,0.0002040758,0.0002160602,0.0008925658],"category_scores_gemma":[0.00008134608,0.0001256447,0.0001414784,0.00006762171,0.00009751751,0.0001462873,0.0001398321,0.0002415539,0.0001648009],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002358062,"about_ca_system_score_gemma":0.0001068524,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004620049,"about_ca_topic_score_gemma":0.001003096,"domain_scores_codex":[0.9999416,0.000004317821,0.000002376092,0.0000157813,0.00001449794,0.00002142833],"domain_scores_gemma":[0.9999739,0.000004239333,0.000008754513,0.000002544666,0.000004116669,0.000006426138],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003624037,0.00001233069,0.00004092825,0.0000203732,0.000002473882,0.00003238479,0.00001157328,0.0001412347,0.9983023,0.0001612367,0.00003980477,0.001198902],"study_design_scores_gemma":[0.000005064389,0.00006122622,0.0003029688,8.839888e-7,0.00000326921,0.0000305062,0.000006555344,0.001229873,0.9978436,0.00002144576,0.0004927051,0.000001866029],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9919372,0.0003422197,0.005532034,0.00005706905,0.00002370461,0.00001999496,0.00005111944,0.0001040639,0.00193264],"genre_scores_gemma":[0.9969966,0.000101414,0.001619301,0.00001361912,0.000001996561,0.000007123088,0.00002699354,0.000008336459,0.001224569],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008925658,"threshold_uncertainty_score":0.002985954,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008821250465403017,"score_gpt":0.2310568569631764,"score_spread":0.2222356064977734,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}