{"id":"W4411255343","doi":"10.1002/ajh.27736","title":"Integrative Genomic and Transcriptomic Analysis Reveals Targetable Vulnerabilities in Angioimmunoblastic T‐Cell Lymphoma","year":2025,"lang":"en","type":"article","venue":"American Journal of Hematology","topic":"Lymphoma Diagnosis and Treatment","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto General Hospital; University of Toronto; University Health Network","funders":"National Cancer Institute; National Institutes of Health; Norges Forskningsråd; Leukemia and Lymphoma Society","keywords":"Angioimmunoblastic T-cell lymphoma; Transcriptome; Lymphoma; Medicine; Cancer research; Computational biology; Oncology; Internal medicine; Biology; Immunology; T cell; Gene; Genetics; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009561165,0.0001357914,0.0001326831,0.0004424308,0.00009273382,0.0001976409,0.00009857078,0.0001435433,0.0009018445],"category_scores_gemma":[0.0001510555,0.00007327202,0.000160072,0.0003078684,0.0001114571,0.00005540829,0.0001538404,0.0001299593,0.0001518272],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001508335,"about_ca_system_score_gemma":0.00008127032,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004234411,"about_ca_topic_score_gemma":0.0007828478,"domain_scores_codex":[0.9999353,0.00000717277,0.000003121156,0.00002361604,0.00001642186,0.00001433778],"domain_scores_gemma":[0.9999433,0.00001824783,0.00001744684,0.000005787963,0.000005537549,0.000009855295],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0002626456,0.00002609825,0.01602514,0.00004074506,0.0000366626,0.0006125854,0.00005152878,0.0003277742,0.9752371,0.0001410813,0.0001393347,0.007099369],"study_design_scores_gemma":[0.00008347302,0.0006899626,0.6927686,0.000018348,0.0003291664,0.006218945,0.0002494715,0.00942698,0.2831056,0.0009831742,0.006107509,0.00001870461],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9961982,0.0003189378,0.001788092,0.00004095124,0.00000436054,0.00001128062,0.001090466,0.00005804446,0.0004895912],"genre_scores_gemma":[0.9974024,0.0001304621,0.001123355,0.00004000972,0.000004763624,0.0000125414,0.0009751517,0.00001077576,0.0003006214],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009018445,"threshold_uncertainty_score":0.003017008,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004244613251270105,"score_gpt":0.2498527728107129,"score_spread":0.2456081595594428,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}