{"id":"W4411257930","doi":"10.1016/j.jbc.2025.108751","title":"Abstract 2816 CRISPR screens identify GSR as a vulnerability for KEAP1/NRF2 mutant NSCLC","year":2025,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Cytokine Signaling Pathways and Interactions","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Cancer Research","funders":"","keywords":"Mutant; CRISPR; Biology; Cancer research; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0005674419,0.0001666971,0.0004725548,0.00004793,0.0001030496,0.00003380461,0.0001687469,0.0002429071,0.0009968728],"category_scores_gemma":[0.002409366,0.0001085803,0.0005373302,0.0001310104,0.0001083424,0.0000570978,0.00004330329,0.0006506774,0.000007702117],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000123642,"about_ca_system_score_gemma":0.0002222985,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001865433,"about_ca_topic_score_gemma":7.822987e-7,"domain_scores_codex":[0.9986057,0.00002015579,0.0007383824,0.0002247887,0.0001780986,0.0002328501],"domain_scores_gemma":[0.998418,0.0003788935,0.0003250114,0.0002103471,0.0004874276,0.0001803551],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009214708,0.0004278679,0.002440532,0.0001393397,0.0001472172,0.00006750053,0.00001383134,0.000005215817,0.9900516,0.00003834668,0.003646702,0.00210042],"study_design_scores_gemma":[0.00159042,0.0004525213,0.02428281,0.0004689411,0.0001324971,0.0004413047,0.0002433755,0.0000359767,0.9480397,0.001486879,0.02269366,0.0001318993],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9873001,0.0003734805,0.001198015,0.00218746,0.00026534,0.0001674568,0.00004268067,0.00002696961,0.00843852],"genre_scores_gemma":[0.9976879,0.00006697198,0.0005903902,0.0005882708,0.0005697372,0.000008750661,0.00001857565,0.000007469929,0.0004619085],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04201184,"threshold_uncertainty_score":0.9999164,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05034103760810205,"score_gpt":0.3758651134691849,"score_spread":0.3255240758610828,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}