{"id":"W4411272894","doi":"10.1371/journal.pone.0322353","title":"The dichotomous impacts of Semaphorin3E deficiency on exacerbating airway hyperresponsiveness, remodelling, and inflammation in type-2 low and type-2 high asthma models","year":2025,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Axon Guidance and Neuronal Signaling","field":"Neuroscience","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"Canadian Institutes of Health Research","keywords":"Asthma; Inflammation; Immunology; Medicine; Airway hyperresponsiveness","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003215389,0.0005370442,0.0004241032,0.0004757588,0.000277956,0.0004452674,0.0002886733,0.0007654228,0.001868121],"category_scores_gemma":[0.0001281907,0.0002589446,0.0006160787,0.0001708902,0.0005537217,0.000397845,0.0003897372,0.001598962,0.0003163528],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002843146,"about_ca_system_score_gemma":0.0003406263,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004249338,"about_ca_topic_score_gemma":0.001114738,"domain_scores_codex":[0.9995509,0.00008224479,0.00006341914,0.00008608436,0.0001037523,0.0001135568],"domain_scores_gemma":[0.9997367,0.00001702125,0.00007062707,0.00002558375,0.00001781311,0.0001322154],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006104287,0.0002352033,0.0008993795,0.00005986385,0.00001116775,0.0001556503,0.00001884833,0.0000479274,0.9969639,0.00008537817,0.00004976162,0.0008624991],"study_design_scores_gemma":[0.0002556621,0.006196187,0.05645373,0.00005070858,0.000150763,0.002421852,0.0003471395,0.001424608,0.9280829,0.0002990302,0.004288173,0.00002923998],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9964042,0.0008968859,0.001096169,0.0001707156,0.00004744218,0.00005736805,0.0004856956,0.00004064455,0.0008009916],"genre_scores_gemma":[0.9928753,0.0007674302,0.001933047,0.000201969,0.00002451485,0.0001615874,0.0007226449,0.00002541124,0.003288175],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001868121,"threshold_uncertainty_score":0.006249487,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03978550977426868,"score_gpt":0.2474541757934131,"score_spread":0.2076686660191444,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}