{"id":"W4411275160","doi":"10.21203/rs.3.rs-6834797/v1","title":"Pilot, open, prospective, randomized, multicentre trial on quality assessment of declined liver grafts by normothermic ex vivo machine perfusion for decreasing time to transplantation: study protocol for the ExTra-Trial","year":2025,"lang":"en","type":"preprint","venue":"Research Square","topic":"Organ Transplantation Techniques and Outcomes","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":false,"ca_institutions":"Toronto General Hospital","funders":"Rijksuniversiteit Groningen; Deutsche Forschungsgemeinschaft; Queen Elizabeth Hospital Birmingham Charity","keywords":"Medicine; Ex vivo; Liver transplantation; Machine perfusion; Transplantation; Perfusion; Protocol (science); Randomized controlled trial; Clinical trial; Surgery; In vivo; Internal medicine; Pathology; Biology; Biotechnology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.007414583,0.003459954,0.005114198,0.0004276029,0.0008662963,0.00184349,0.001347243,0.002782826,0.0200152],"category_scores_gemma":[0.009923518,0.0009942212,0.002968399,0.0006416762,0.002311548,0.001790855,0.001305566,0.003723746,0.003311903],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001092437,"about_ca_system_score_gemma":0.002913565,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001097379,"about_ca_topic_score_gemma":0.001295716,"domain_scores_codex":[0.9964618,0.002243997,0.0002267781,0.0004563172,0.0001732341,0.0004379525],"domain_scores_gemma":[0.995095,0.001947183,0.0008470834,0.0007856807,0.0004633867,0.0008617344],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9928414,0.002488327,0.0002049562,0.0004167239,0.0004948882,0.00002300652,0.00002710846,0.0001521051,0.0003686229,0.0001636747,0.0006865782,0.002132547],"study_design_scores_gemma":[0.9794577,0.0188001,0.0005744091,0.00003317466,0.0002516923,0.000009869657,0.00001329123,0.0001345156,0.00009403841,0.0002087709,0.0004122019,0.00001015944],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"protocol","genre_scores_codex":[0.6800077,0.004909855,0.01206313,0.00377762,0.003706574,0.2729872,0.01151988,0.0008596584,0.01016842],"genre_scores_gemma":[0.6538056,0.00159827,0.01384507,0.00320007,0.001445758,0.3128196,0.004928304,0.0001216395,0.008235631],"genre_candidate":"protocol","genre_consensus":null,"teacher_disagreement_score":0.0200152,"threshold_uncertainty_score":0.06695753,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1389246454833852,"score_gpt":0.5255935771616327,"score_spread":0.3866689316782475,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}