{"id":"W4411275540","doi":"10.1016/j.clgc.2025.102385","title":"Comorbidity Burden and Effectiveness of Immunotherapy in Metastatic Renal Cell Carcinoma","year":2025,"lang":"en","type":"article","venue":"Clinical Genitourinary Cancer","topic":"Renal cell carcinoma treatment","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Calgary","funders":"Dana-Farber Cancer Institute","keywords":"Medicine; Discontinuation; Comorbidity; Internal medicine; Hazard ratio; Renal cell carcinoma; Nivolumab; Adverse effect; Oncology; Confidence interval; Cancer; Immunotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007103021,0.0001850117,0.0007359018,0.0001418616,0.00002894449,0.000005722284,0.00009616391,0.00009723495,0.0000661617],"category_scores_gemma":[0.00005105315,0.0001516137,0.0001864903,0.0002533302,0.0002065449,0.00003558002,0.00008192169,0.0003042412,0.000003671361],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001544829,"about_ca_system_score_gemma":0.0003400482,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005477768,"about_ca_topic_score_gemma":0.00001906285,"domain_scores_codex":[0.9981554,0.0004889905,0.0006036581,0.0003810861,0.0001608156,0.00021008],"domain_scores_gemma":[0.9984539,0.000885019,0.000118173,0.0003695556,0.0000739052,0.00009948933],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.005958376,0.0007783,0.9320919,0.001289331,0.0002544255,0.0006217182,0.00009435767,0.00008094616,0.02338699,0.00002994499,0.00020525,0.03520844],"study_design_scores_gemma":[0.007098683,0.001234174,0.9571031,0.0004228457,0.0002001568,0.0000140105,0.00004390969,0.0001192804,0.03262224,0.0002132916,0.0008134181,0.0001149278],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9817001,0.01502173,0.00002987092,0.000297437,0.0002636578,0.0006885813,0.00001412022,0.00001239031,0.001972164],"genre_scores_gemma":[0.9972156,0.001615502,0.0003502233,0.00009038369,0.0001287217,0.0001027734,0.0000100259,0.00001735017,0.000469423],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03509351,"threshold_uncertainty_score":0.6182628,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04757200492122552,"score_gpt":0.3814665025954285,"score_spread":0.3338944976742029,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}