{"id":"W4411275540","doi":"10.1016/j.clgc.2025.102385","title":"Comorbidity Burden and Effectiveness of Immunotherapy in Metastatic Renal Cell Carcinoma","year":2025,"lang":"en","type":"article","venue":"Clinical Genitourinary Cancer","topic":"Renal cell carcinoma treatment","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Calgary","funders":"Dana-Farber Cancer Institute","keywords":"Medicine; Discontinuation; Comorbidity; Internal medicine; Hazard ratio; Renal cell carcinoma; Nivolumab; Adverse effect; Oncology; Confidence interval; Cancer; Immunotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005036998,0.000122352,0.0004978855,0.0003805105,0.0003467831,0.0006345172,0.0002380364,0.0003322474,0.001890627],"category_scores_gemma":[0.005453554,0.0001062758,0.0008139477,0.0009973994,0.0001785656,0.0004364135,0.0004955666,0.000550012,0.0001174062],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008383392,"about_ca_system_score_gemma":0.000659106,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005158517,"about_ca_topic_score_gemma":0.008320829,"domain_scores_codex":[0.9994757,0.0001800553,0.00007450272,0.00005939688,0.0001012761,0.0001091409],"domain_scores_gemma":[0.9976539,0.0005078118,0.001158122,0.00008349234,0.0001367774,0.0004598964],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001674599,0.0001061375,0.9823536,0.00005942669,0.0004699341,0.00007688507,0.00002955473,0.0007841301,0.0003348253,0.0001677698,0.0004519952,0.01349119],"study_design_scores_gemma":[0.00002660065,0.0002378776,0.9980075,0.00001886565,0.0001453745,0.0002020045,0.00006353134,0.0007365725,0.00005505106,0.0001294867,0.0003718375,0.000005382595],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9923942,0.004831492,0.00009687823,0.000598855,0.00003284101,0.000005703056,0.0005009821,0.000004641927,0.001534273],"genre_scores_gemma":[0.9987963,0.0005711431,0.00004147967,0.00006438512,0.00005010895,0.000002466625,0.0003632577,0.000001789501,0.0001090708],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005158517,"threshold_uncertainty_score":0.01025695,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04757200492122552,"score_gpt":0.3814665025954285,"score_spread":0.3338944976742029,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}