{"id":"W4411277399","doi":"10.1002/pbc.31852","title":"PD‐L1 Expression is Mediated by microRNA Processing, Wnt/β‐Catenin Signaling, and Chemotherapy in Wilms Tumor","year":2025,"lang":"en","type":"article","venue":"Pediatric Blood & Cancer","topic":"Renal and related cancers","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network","funders":"National Cancer Institute; National Institutes of Health; University of Texas MD Anderson Cancer Center; Cancer Prevention and Research Institute of Texas; Pablove Foundation; University of Texas Southwestern Medical Center; Alex's Lemonade Stand Foundation for Childhood Cancer; U.S. Department of Defense","keywords":"Wnt signaling pathway; Medicine; Wilms' tumor; microRNA; Cancer research; Chemotherapy; Catenin; Wilms tumour; Signal transduction; Internal medicine; Cell biology; Genetics; Biology; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000164219,0.0001347704,0.0001255253,0.0004220743,0.0001094227,0.0002845587,0.00008089794,0.0001216363,0.0006116154],"category_scores_gemma":[0.0002310562,0.000110104,0.0001211345,0.0002183853,0.0002027972,0.0001516139,0.0001210065,0.0001817453,0.0001109146],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004434801,"about_ca_system_score_gemma":0.0002430866,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004000287,"about_ca_topic_score_gemma":0.00065962,"domain_scores_codex":[0.9999013,0.00001577409,0.000008331488,0.00002594005,0.000031249,0.00001745451],"domain_scores_gemma":[0.9998759,0.0000203634,0.00006688935,0.000005990729,0.00001107435,0.00001975259],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005052034,0.00003124181,0.04420636,0.00008068344,0.00002802271,0.0002416832,0.00005956746,0.0003896593,0.9485335,0.0001463621,0.0001888032,0.005588962],"study_design_scores_gemma":[0.00001545179,0.0002709191,0.3920709,0.0000103322,0.0000419612,0.001111652,0.0001093825,0.002333542,0.6013933,0.0001284478,0.002507129,0.000006851735],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9973298,0.001255213,0.0006876562,0.0000401824,0.000003961808,0.000008762371,0.000257802,0.00003331308,0.000383359],"genre_scores_gemma":[0.9983031,0.0004403377,0.0006444957,0.00002178747,0.000002668386,0.00001136779,0.0002917653,0.000005394927,0.0002792109],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006116154,"threshold_uncertainty_score":0.003217638,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.002757964706235141,"score_gpt":0.2304154515755412,"score_spread":0.227657486869306,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}