{"id":"W4411283309","doi":"10.3390/ijms26125680","title":"The Anti-Parkinsonian A2A Receptor Antagonist Istradefylline (KW-6002) Attenuates Behavioral Abnormalities, Neuroinflammation, and Neurodegeneration in Cerebral Ischemia: An Adenosinergic Signaling Link Between Stroke and Parkinson’s Disease","year":2025,"lang":"en","type":"article","venue":"International Journal of Molecular Sciences","topic":"Adenosine and Purinergic Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan","funders":"University of Saskatchewan; Natural Sciences and Engineering Research Council of Canada; Heart and Stroke Foundation of Canada","keywords":"Medicine; Neurodegeneration; Neuroinflammation; Adenosinergic; Stroke (engine); Neuroprotection; Pharmacology; Disease; Antagonist; Ischemia; Receptor; Neuroscience; Internal medicine; Agonist; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001013244,0.000613426,0.0007766663,0.0003915648,0.0001780365,0.0001899739,0.0003209322,0.0005059448,0.001566356],"category_scores_gemma":[0.00008249276,0.0001902016,0.0003289529,0.0002252561,0.0002439921,0.0003662528,0.0001456577,0.001274042,0.0003383013],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001933971,"about_ca_system_score_gemma":0.0003822463,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001015328,"about_ca_topic_score_gemma":0.002705389,"domain_scores_codex":[0.9999156,0.000009464946,0.00001323168,0.00001263259,0.00001923774,0.00002988225],"domain_scores_gemma":[0.9999244,0.000003868805,0.00002202545,0.000006351696,0.00001020653,0.00003300524],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003234628,0.000912927,0.0002525955,0.00024944,0.00004951903,0.0001250416,0.00003311618,0.00007217623,0.9853024,0.00008878573,0.0002505275,0.009428784],"study_design_scores_gemma":[0.001103757,0.01884734,0.02014183,0.00005734717,0.0002243582,0.0006782461,0.0001341604,0.001118073,0.9518591,0.0001721603,0.005632018,0.00003159684],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9918093,0.004972493,0.0008509987,0.0002550737,0.00009984085,0.00005265108,0.000509827,0.0001256822,0.001324232],"genre_scores_gemma":[0.9889309,0.005715258,0.00128018,0.000194476,0.00005041887,0.0001224492,0.0007875707,0.00001417523,0.002904624],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001566356,"threshold_uncertainty_score":0.005239964,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0125745276131352,"score_gpt":0.2783085594705498,"score_spread":0.2657340318574146,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}