{"id":"W4411285509","doi":"10.1158/1557-3265.sabcs24-p3-08-22","title":"Abstract P3-08-22: Tucatinib, Trastuzumab and Capecitabine with brain and/or spinal radiotherapy (XRT) in patients with HER2+ metastatic breast cancer and leptomeningeal disease: A multi-centre phase II, single arm feasibility study (\"CLIMB LMD\"; NCT06016387)","year":2025,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Brain Metastases and Treatment","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Capecitabine; Trastuzumab; Medicine; Radiation therapy; Metastatic breast cancer; Breast cancer; Oncology; Cancer; Internal medicine; Colorectal cancer","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002427139,0.001681684,0.002086081,0.0003976837,0.0006577612,0.001281754,0.00130745,0.0015865,0.007283056],"category_scores_gemma":[0.00105688,0.0007157435,0.001459767,0.0006229779,0.0009616484,0.0008823659,0.0005096277,0.003471911,0.001741117],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002028104,"about_ca_system_score_gemma":0.006045513,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.006997256,"about_ca_topic_score_gemma":0.02172926,"domain_scores_codex":[0.9993402,0.0003244387,0.00003693798,0.00009081738,0.0000710554,0.0001366126],"domain_scores_gemma":[0.9986517,0.0001027056,0.0002385996,0.000061698,0.0001081539,0.0008372786],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.8810152,0.05622316,0.005786208,0.0007733353,0.0009176299,0.0001877345,0.0001796541,0.0009087677,0.01548152,0.0001185863,0.006178136,0.03223009],"study_design_scores_gemma":[0.7238236,0.2609897,0.01146757,0.00003254911,0.00029157,0.0001135845,0.00004827386,0.000335408,0.0009903505,0.00006214609,0.001825159,0.00002013083],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9796228,0.00143595,0.000419921,0.0009059134,0.000139057,0.01092403,0.003709866,0.0001171958,0.002725183],"genre_scores_gemma":[0.9753996,0.001184292,0.001695273,0.001574553,0.0002364401,0.01123016,0.004309934,0.000037507,0.004332372],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007283056,"threshold_uncertainty_score":0.02436429,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1302687441927209,"score_gpt":0.5033111665503891,"score_spread":0.3730424223576683,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}