{"id":"W4411286445","doi":"10.1158/1557-3265.sabcs24-p5-03-01","title":"Abstract P5-03-01: Open-label, randomized, multicenter, phase 3, ELAINE 3 study of the efficacy and safety of lasofoxifene plus abemaciclib for treating ER+/HER2-, locally advanced or metastatic breast cancer with an ESR1 mutation","year":2025,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Advanced Breast Cancer Therapies","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Medicine; Metastatic breast cancer; Oncology; Breast cancer; Phases of clinical research; Cancer; Internal medicine; Open label; Randomized controlled trial; Clinical trial","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00422214,0.0003376545,0.001837299,0.0001883888,0.0002917729,0.00004922323,0.0005823919,0.0001038185,0.0001732644],"category_scores_gemma":[0.002080754,0.0001933049,0.000118865,0.0009369068,0.001315754,0.0003142789,0.0002763448,0.0007022426,6.158836e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003454637,"about_ca_system_score_gemma":0.001795958,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002111387,"about_ca_topic_score_gemma":0.003974465,"domain_scores_codex":[0.9950395,0.0009979182,0.00169923,0.0008416774,0.0008545693,0.0005671405],"domain_scores_gemma":[0.9903127,0.00652063,0.0006748025,0.0008034862,0.001434393,0.0002539666],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.671713,0.005849095,0.001397553,0.0007762809,0.001123715,0.0000174202,0.0007834056,0.0007627976,0.001352784,0.0000411203,0.00001749485,0.3161653],"study_design_scores_gemma":[0.9468942,0.01007941,0.0253841,0.00384673,0.001087324,0.00001592544,0.004240267,0.005686271,0.002105463,0.0001362086,0.0002415957,0.0002824704],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9826078,0.001729454,0.001121185,0.001698791,0.0001747025,0.01221587,0.0003445086,0.00002943927,0.00007818791],"genre_scores_gemma":[0.9923824,0.0008459184,0.003543413,0.0002067593,0.000122424,0.002279179,0.00002327193,0.00006863406,0.0005279771],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3158828,"threshold_uncertainty_score":0.7882745,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1548699941123187,"score_gpt":0.5548477553664776,"score_spread":0.3999777612541588,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}