{"id":"W4411287522","doi":"10.1158/1557-3265.sabcs24-p1-03-28","title":"Abstract P1-03-28: Agreement between the DESTINY-Breast04/06 VENTANA 4B5 HER2 IHC clinical trial assay and other comparator assays for HER2-low breast cancer: Overall results of a large-scale, multicenter global ring study","year":2025,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Advanced Breast Cancer Therapies","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Medicine; Breast cancer; Immunohistochemistry; Pathology; Cancer; Oncology; Internal medicine","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.01384877,0.0004855987,0.001711134,0.0001436197,0.0004025289,0.00009872869,0.0007953978,0.0003812748,0.0001800728],"category_scores_gemma":[0.001395684,0.0003503069,0.0005572456,0.0006417182,0.001213996,0.0001436572,0.0005695412,0.001744932,0.0000186009],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007542521,"about_ca_system_score_gemma":0.001216197,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003494681,"about_ca_topic_score_gemma":0.003702599,"domain_scores_codex":[0.9914488,0.001439437,0.002895816,0.001443221,0.001526092,0.001246671],"domain_scores_gemma":[0.9908588,0.005652091,0.0006614852,0.001258678,0.000993929,0.0005750022],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.1356218,0.00402657,0.8033336,0.0003486061,0.001569353,0.00001928314,0.0002779994,0.00004286226,0.00002424241,0.00006794069,0.003595871,0.05107186],"study_design_scores_gemma":[0.1273447,0.001936533,0.8465815,0.001284196,0.0004522509,0.000004702397,0.001119799,0.0005431431,0.00005271282,0.0002573587,0.02012164,0.000301514],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9789103,0.001841484,0.00026533,0.007014248,0.0009425103,0.006820543,0.003263248,0.00006656275,0.0008757326],"genre_scores_gemma":[0.9941745,0.0003002925,0.000433246,0.0007589199,0.002597106,0.001051543,0.00003580077,0.00006564462,0.0005828814],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05077034,"threshold_uncertainty_score":0.9998949,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2064113583818722,"score_gpt":0.5548789198231137,"score_spread":0.3484675614412415,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}