{"id":"W4411287522","doi":"10.1158/1557-3265.sabcs24-p1-03-28","title":"Abstract P1-03-28: Agreement between the DESTINY-Breast04/06 VENTANA 4B5 HER2 IHC clinical trial assay and other comparator assays for HER2-low breast cancer: Overall results of a large-scale, multicenter global ring study","year":2025,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Advanced Breast Cancer Therapies","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Medicine; Breast cancer; Immunohistochemistry; Pathology; Cancer; Oncology; Internal medicine","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.03147451,0.0008559304,0.000988977,0.0007453468,0.0003470744,0.00106046,0.001170876,0.0008961734,0.002806305],"category_scores_gemma":[0.01828118,0.0004120721,0.001284797,0.0006570954,0.001016469,0.0008859737,0.001742805,0.0008605722,0.001115237],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00065344,"about_ca_system_score_gemma":0.0004714421,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007942379,"about_ca_topic_score_gemma":0.001246311,"domain_scores_codex":[0.977685,0.01565771,0.001038024,0.003063303,0.002233575,0.0003224341],"domain_scores_gemma":[0.9692326,0.01341365,0.006662033,0.004142951,0.004986574,0.001562306],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.2986514,0.002314433,0.5815233,0.001471036,0.01219783,0.0001311367,0.001058539,0.003257425,0.02815558,0.0003152812,0.01075228,0.06017179],"study_design_scores_gemma":[0.01898749,0.04179858,0.9051512,0.0001477966,0.005353236,0.000588685,0.0003294533,0.005567069,0.01613955,0.0002811164,0.005520393,0.0001355403],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9850033,0.002254938,0.003343144,0.0001699552,0.000060436,0.0009803533,0.004827669,0.0001402893,0.003219892],"genre_scores_gemma":[0.9908748,0.0001328292,0.002527888,0.0002292681,0.00004674431,0.0005256819,0.004903742,0.00006761657,0.0006914933],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03147451,"threshold_uncertainty_score":0.1664551,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2064113583818722,"score_gpt":0.5548789198231137,"score_spread":0.3484675614412415,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}