{"id":"W4411300972","doi":"10.1158/2159-8290.cd-24-1500","title":"Phase Ib Basket Expansion Trial and Alternative-Schedule Dose-Escalation Study of ATR Inhibitor Elimusertib in Advanced Solid Tumors with DNA Damage Response Defects","year":2025,"lang":"en","type":"article","venue":"Cancer Discovery","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Centre hospitalier universitaire de Québec","funders":"National Institutes of Health; Bayer; U.S. Department of Defense","keywords":"DNA damage; DNA; Schedule; Phase (matter); Maximum tolerated dose; Cancer research; Computational biology; Medicine; Biology; Chemistry; Clinical trial; Genetics; Internal medicine; Computer science","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00025214,0.0001744888,0.0002521992,0.0001099478,0.00004061546,0.00002484374,0.0001073536,0.00007364538,0.000003093456],"category_scores_gemma":[0.0001218613,0.0001532382,0.00004150494,0.000180209,0.00005209288,0.00003520892,0.000115048,0.00008455,2.1335e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005567673,"about_ca_system_score_gemma":0.0002317865,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005171315,"about_ca_topic_score_gemma":0.0004122301,"domain_scores_codex":[0.9987506,0.0001930165,0.000281873,0.000446206,0.0001519733,0.000176311],"domain_scores_gemma":[0.9993965,0.00004222333,0.0001391321,0.0003238625,0.00005462001,0.00004365768],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.09885303,0.0008954628,0.002490109,0.00003649336,0.0000473984,0.00001156407,0.0002378666,0.0007923139,0.8956006,0.00001048103,0.00002567424,0.000999061],"study_design_scores_gemma":[0.05798168,0.005878983,0.008542092,0.0002141638,0.00004062922,6.987232e-7,0.0008734483,0.0002617213,0.9259341,0.00002957496,0.00005851364,0.0001843625],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9980544,0.0002651797,0.000376367,0.0000283131,0.0002302661,0.0009738638,0.00002951387,0.00001005805,0.00003197484],"genre_scores_gemma":[0.9992603,0.0000521889,0.00009575596,0.00005588162,0.00007688761,0.0001819599,0.0000261451,0.00002061243,0.0002302829],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04087135,"threshold_uncertainty_score":0.6248872,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009876035978115252,"score_gpt":0.3082849068221279,"score_spread":0.2984088708440126,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}