{"id":"W4411302114","doi":"10.1016/j.actbio.2025.06.017","title":"Co-assembly of oligo-urethane nanoparticles with defined lipid additives to tailor RNA delivery into cells","year":2025,"lang":"en","type":"article","venue":"Acta Biomaterialia","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Hospital for Sick Children; University of Toronto; Ted Rogers Centre for Heart Research","funders":"Hospital for Sick Children; University of Toronto","keywords":"Materials science; Nanoparticle; Nanotechnology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000174833,0.0002865162,0.0001713949,0.00016935,0.0001315578,0.0002547309,0.0001615768,0.0002568937,0.0005799618],"category_scores_gemma":[0.0001458756,0.0001571022,0.0002165893,0.0001437894,0.0001259961,0.0001642526,0.0002213904,0.0002817769,0.0003161037],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002528891,"about_ca_system_score_gemma":0.0002040484,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004474607,"about_ca_topic_score_gemma":0.001163065,"domain_scores_codex":[0.99985,0.00002074284,0.00001440063,0.00004335682,0.0000374337,0.00003399852],"domain_scores_gemma":[0.9999173,0.00002003465,0.00002016503,0.0000109357,0.00001375077,0.00001785153],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002578657,0.000009153357,0.00003515409,0.00001429275,0.000003153433,0.00001894673,0.00001049258,0.00008758146,0.9990221,0.00005766037,0.00001357875,0.0007021283],"study_design_scores_gemma":[0.000002628544,0.00004207368,0.0001878411,0.00000116544,0.000005433687,0.00001598895,0.000003039708,0.0005615514,0.9985084,0.000006419738,0.0006636317,0.000001764921],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9865755,0.0008007743,0.009188154,0.00005669533,0.00005107353,0.00004611857,0.000073797,0.0001457426,0.003062151],"genre_scores_gemma":[0.9881593,0.0003689737,0.006939836,0.00005262226,0.00001031023,0.00005103701,0.0001008943,0.00003728731,0.004279643],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005799618,"threshold_uncertainty_score":0.001940131,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007062783446987261,"score_gpt":0.2454580291106547,"score_spread":0.2383952456636674,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}