{"id":"W4411310044","doi":"10.1007/978-1-0716-4615-1_20","title":"Strategy and Application of Viral Potency Assays in Cell and Gene Therapy","year":2025,"lang":"en","type":"review","venue":"Methods in molecular biology","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Calgary","funders":"","keywords":"Potency; Genetic enhancement; Computational biology; Virology; Biology; Gene; Genetics; In vitro","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002024374,0.001861352,0.002263306,0.003708324,0.0003608142,0.001866003,0.001822687,0.001723035,0.002060615],"category_scores_gemma":[0.001417699,0.0008681907,0.0008151287,0.003449992,0.001658183,0.002101707,0.001226533,0.003328907,0.00203729],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001830604,"about_ca_system_score_gemma":0.001506695,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001834143,"about_ca_topic_score_gemma":0.001987694,"domain_scores_codex":[0.9994441,0.0001088171,0.00004847674,0.00009475801,0.0002492466,0.00005464918],"domain_scores_gemma":[0.9994479,0.0003381566,0.00004985744,0.00002443657,0.0001163176,0.00002340626],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00009969588,0.0001684817,0.0001744226,0.01391915,0.00009434867,0.000308858,0.00009331575,0.001431259,0.01509012,0.03134054,0.01764882,0.9196311],"study_design_scores_gemma":[0.0000226982,0.000153087,0.0004900186,0.001968103,0.0001123904,0.001015747,0.00004810949,0.0005319045,0.008262443,0.007540394,0.9797934,0.00006174824],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001740216,0.9953427,0.002351502,0.0001806521,0.0002604739,0.00001593089,0.00002992941,0.00001351696,0.001631395],"genre_scores_gemma":[0.001439625,0.9948596,0.002001343,0.0002083141,0.0001470343,0.00002843022,0.0000527527,0.000004972219,0.001258011],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003708324,"threshold_uncertainty_score":0.01328206,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03513520992179688,"score_gpt":0.4500663468538093,"score_spread":0.4149311369320124,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}