{"id":"W4411319185","doi":"10.1016/j.annonc.2025.04.012","title":"Breast cancer germline multigene panel testing in mainstream oncology based on clinical–public health utility: ESMO Precision Oncology Working Group recommendations","year":2025,"lang":"en","type":"article","venue":"Annals of Oncology","topic":"BRCA gene mutations in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"European Society for Medical Oncology; Cancer Research UK","keywords":"CHEK2; Medicine; PALB2; Oncology; Breast cancer; Internal medicine; Cancer; PTEN; Genetic testing; Germline mutation; Genetics; Gene; Biology; Mutation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.1171228,0.002148322,0.002595813,0.006587369,0.001937934,0.005320246,0.01165396,0.02295438,0.005362324],"category_scores_gemma":[0.1349729,0.001226024,0.005233137,0.003794315,0.003171617,0.005580989,0.008338491,0.01316788,0.004629285],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.004737324,"about_ca_system_score_gemma":0.02898152,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0239779,"about_ca_topic_score_gemma":0.01796225,"domain_scores_codex":[0.9374571,0.02584472,0.009954564,0.003296726,0.01988041,0.003566488],"domain_scores_gemma":[0.800697,0.06772075,0.01261639,0.006343307,0.09965917,0.01296346],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002958761,0.0003424045,0.01035009,0.003871082,0.0004831803,0.000482759,0.000966355,0.002839669,0.001149739,0.01518812,0.7038826,0.2601479],"study_design_scores_gemma":[0.0003833189,0.0004835721,0.02035544,0.03178071,0.0009507195,0.0007075964,0.001002909,0.003729402,0.001651436,0.02590085,0.9128263,0.000227671],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"methods","genre_scores_codex":[0.005979505,0.07559768,0.0459754,0.7562081,0.01783715,0.004275281,0.006333509,0.001600763,0.08619262],"genre_scores_gemma":[0.07372468,0.08171152,0.3368248,0.4461845,0.01465286,0.009797078,0.01520844,0.0007499186,0.02114617],"genre_candidate":"methods","genre_consensus":null,"teacher_disagreement_score":0.1171228,"threshold_uncertainty_score":0.6194118,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2826800938487806,"score_gpt":0.4898417717518745,"score_spread":0.2071616779030939,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}