{"id":"W4411319543","doi":"10.1101/2025.06.13.659636","title":"Scalable expansion and hepatic zone maturation of hepatic progenitor cells from human pluripotent stem cells","year":2025,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Liver physiology and pathology","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Toronto General Hospital; Stem Cell Network; University Health Network","funders":"Stem Cell Network","keywords":"Progenitor cell; Induced pluripotent stem cell; Cell biology; Stem cell; Human Induced Pluripotent Stem Cells; Progenitor; Biology; Embryonic stem cell; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001923615,0.000241179,0.0001269043,0.0001904411,0.0001063473,0.0002999693,0.0001238786,0.0001525296,0.0009295975],"category_scores_gemma":[0.0001168379,0.0001385284,0.0001478848,0.0001444135,0.0001475911,0.0001581781,0.0003332425,0.0003400943,0.0004048951],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001339535,"about_ca_system_score_gemma":0.0001475671,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002887358,"about_ca_topic_score_gemma":0.0004967649,"domain_scores_codex":[0.999931,0.00000691931,0.000008026594,0.00001492648,0.00002778567,0.00001139017],"domain_scores_gemma":[0.9999509,0.00001065222,0.00001128017,0.000009621967,0.000009396781,0.000008057785],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001389095,0.000004005736,0.00005922971,0.00001373771,0.000001101819,0.00001503057,0.00001112039,0.0001724738,0.9985684,0.00008385067,0.00002656096,0.001030534],"study_design_scores_gemma":[0.000005597866,0.00004333617,0.0007019429,0.000002819736,0.000003660926,0.00004467064,0.000006621196,0.001015233,0.9962413,0.00003027257,0.001902362,0.000002102377],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9078965,0.001001286,0.08529335,0.00008440488,0.00005672997,0.0002352338,0.00114768,0.0004649061,0.003819923],"genre_scores_gemma":[0.9574066,0.0007248588,0.03760551,0.00003009724,0.00001104205,0.0001594859,0.001129181,0.0001079142,0.002825178],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009295975,"threshold_uncertainty_score":0.003109813,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01319668523634666,"score_gpt":0.2243229240140013,"score_spread":0.2111262387776547,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}