{"id":"W4411321314","doi":"10.1007/s40120-025-00771-5","title":"Development and Validation of PARCOMS Composite Scales for Assessing Disease Progression and Treatment Effects in Parkinson’s Disease","year":2025,"lang":"en","type":"article","venue":"Neurology and Therapy","topic":"Parkinson's Disease Mechanisms and Treatments","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Broadcom (Canada)","funders":"Allergan","keywords":"Parkinson's disease; Medicine; Neurology; Disease; Neuroscience; Internal medicine; Psychology; Psychiatry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01335252,0.0006670608,0.0006269137,0.001623504,0.0003762338,0.0008308166,0.0008052863,0.0004533679,0.001350303],"category_scores_gemma":[0.02170686,0.0001981657,0.001377277,0.00100151,0.0003651558,0.0006831084,0.001184977,0.001011367,0.0004345265],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000732968,"about_ca_system_score_gemma":0.00109269,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001939388,"about_ca_topic_score_gemma":0.003052748,"domain_scores_codex":[0.993084,0.003305845,0.0007987437,0.0005325535,0.002117066,0.000161883],"domain_scores_gemma":[0.9847327,0.005141953,0.003980814,0.001080957,0.004457361,0.0006062004],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002118569,0.0005925196,0.7929335,0.0004467617,0.0009030182,0.00006434807,0.0007350305,0.004682116,0.00198677,0.0005972842,0.004354164,0.190586],"study_design_scores_gemma":[0.0001746298,0.001614939,0.9870877,0.0001167316,0.00013841,0.0002242364,0.0001684806,0.005819536,0.0007434649,0.0004212355,0.003462926,0.00002768544],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"methods","genre_scores_codex":[0.9482108,0.00265836,0.02772117,0.0004292901,0.0002058109,0.003102912,0.007189404,0.0003354784,0.01014677],"genre_scores_gemma":[0.9624211,0.0004818281,0.02918039,0.0001121595,0.00006309724,0.002623812,0.00424686,0.0000384862,0.0008323472],"genre_candidate":"methods","genre_consensus":null,"teacher_disagreement_score":0.01335252,"threshold_uncertainty_score":0.07061571,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01839580819391022,"score_gpt":0.3132663788559958,"score_spread":0.2948705706620856,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}